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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study complies to general scientific principles; pre-dates GLP regulations,

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no
Remarks:
Study pre-dates GLP implementation

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,5-trichloroaniline
EC Number:
211-254-9
EC Name:
2,4,5-trichloroaniline
Cas Number:
636-30-6
Molecular formula:
C6H4Cl3N
IUPAC Name:
2,4,5-trichloroaniline

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
- Animals : 3 males, singlly caged
- Environment: 19-21 C; 40-50 % humidity; 12 h light-12 h dark
- Feed: Ssniff K4

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
100 mg per animal
Duration of treatment / exposure:
After application the eye was closed for about 1 second . 24 h thereafter the eye was rinsed with physiologic saline
Observation period (in vivo):
72 h
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72 h
Score:
0.2
Max. score:
1
Reversibility:
fully reversible within: 48 h
Remarks on result:
other: 24 after treatment only 1/3 animals showed erythema
Irritant / corrosive response data:
cornea as well as iris did not show effects. The corneas of all animals showed erythema after one hour but after 24 h only 1 animal still showed changes.
According to 1272 EC the substance is not classified as irritant to the eye.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
2,4,5-Trichloro aniline is not irritating to the rabbit eye.