Registration Dossier
Registration Dossier
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EC number: 210-415-0 | CAS number: 615-20-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1980
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- single oral application (0.5 mL/100g bw) by gavage; recording of symptoms during the observation time of 14 d, followed by gross-pathological evaluation
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorobenzothiazole
- EC Number:
- 210-415-0
- EC Name:
- 2-chlorobenzothiazole
- Cas Number:
- 615-20-3
- Molecular formula:
- C7H4ClNS
- IUPAC Name:
- 2-chloro-1,3-benzothiazole
- Details on test material:
- no purity specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- poloxamer
- Remarks:
- Lutrol (no other data reported)
- Details on oral exposure:
- gavage (0.5 ml/100g bw) before feeding
- Doses:
- 25, 50, 100, 125, 150, 200, 250, 500 mg/kg bw
- No. of animals per sex per dose:
- 15 males only
- Control animals:
- no
- Statistics:
- LD50-calculation according to Litchfield and Wilcoxon 1949
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 139 mg/kg bw
- Based on:
- test mat.
- Mortality:
- see Table below
- Clinical signs:
- other: onset 5-30 min. post application: apathy, rough fur, reduced motility, reversible 1-9 d after application Animals with highest doses applied (250 and 500 mg/kg bw): staggering gait
- Gross pathology:
- (in animals died 1-3 d after application, >= 100 mg /kg bw):
lungs: with emphysemas and edemas
liver: pale and mottled
kidneys: pale
urinary bladder: filled with red urine
stomach: erosions, blood
After 14 d after application: no pathological change detectable in survivors
Any other information on results incl. tables
Results in Detail
Dose (mg/kg bw) |
Rats died (No.) |
Rats with symptoms (No.) |
Rats used (No.) |
Time of death (d) |
25 |
0 |
0 |
15 |
- |
50 |
0 |
15 |
15 |
- |
100 |
1 |
15 |
15 |
1 |
125 |
6 |
15 |
15 |
1-3 |
150 |
11 |
15 |
15 |
1-2 |
200 |
13 |
15 |
15 |
1-2 |
250 |
15 |
15 |
15 |
1-2 |
500 |
15 |
15 |
15 |
1 |
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The LD50rat is 139 mg/kg bw
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