Registration Dossier
Registration Dossier
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EC number: 210-415-0 | CAS number: 615-20-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Application of undiluted substance on a gauze which was fixed on inner surface of each one ear of rabbit for 4 or 8 h
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chlorobenzothiazole
- EC Number:
- 210-415-0
- EC Name:
- 2-chlorobenzothiazole
- Cas Number:
- 615-20-3
- Molecular formula:
- C7H4ClNS
- IUPAC Name:
- 2-chloro-1,3-benzothiazole
- Details on test material:
- no purity specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: none required
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml applied on a small piece of gauze (2.5 cm x 2.5 cm) and then fixed on the inner surface of one ear of rabbit for 4 h or 8 h
- Duration of treatment / exposure:
- 4 h or 8 h
- Observation period:
- 7 d after application
- Number of animals:
- 2 for each exposure period
Results and discussion
In vivo
- Irritant / corrosive response data:
- slight redness of the skin during 2 d, reversible, effect not relevant for classification
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- 2-Chlorobenzothiazole is not irritating to the skin
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