Registration Dossier
Registration Dossier
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EC number: 210-415-0 | CAS number: 615-20-3
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- CRC Handbook of Chemistry and Physics
- Author:
- Weast RC
- Year:
- 1 977
- Bibliographic source:
- CRC Handbook of Chemistry and Physics, 58th edn. CRC Press, Inc., West Palm Beach, Florida, USA
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Thiazole
- EC Number:
- 206-021-3
- EC Name:
- Thiazole
- Cas Number:
- 288-47-1
- IUPAC Name:
- 1,3-thiazole
- Reference substance name:
- Imidazole
- EC Number:
- 206-019-2
- EC Name:
- Imidazole
- Cas Number:
- 288-32-4
- IUPAC Name:
- 1H-imidazole
- Reference substance name:
- Benzimidazole
- EC Number:
- 200-081-4
- EC Name:
- Benzimidazole
- Cas Number:
- 51-17-2
- IUPAC Name:
- 1H-benzimidazole
Constituent 1
Constituent 2
Constituent 3
Results and discussion
- Dissociating properties:
- yes
Dissociation constantopen allclose all
- No.:
- #1
- pKa:
- 2.44
- Remarks on result:
- other: Thiazole (corresponding acid)
- No.:
- #2
- pKa:
- 6.95
- Remarks on result:
- other: Imidazole (corresponding acid)
- No.:
- #3
- pKa:
- 5.53
- Remarks on result:
- other: Benzimidazole (corresponding acid)
Any other information on results incl. tables
From the pKa vaules of the corresponding acids of the above mentioned substances it is deduced that 2 -Chlorobenzothiazole is a weak base. In neutral media, 2 -Chlorobenzothiazole is predominantly in the non-charged molecular form.
Applicant's summary and conclusion
- Conclusions:
- From the pKa vaules of the corresponding acids of the above mentioned substances it is derived that 2 -Chlorobenzothiazole is a weak base. In neutral media, 2 -Chlorobenzothiazole is predominantly in the non-charged molecular form.
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