Registration Dossier
Registration Dossier
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EC number: 210-415-0 | CAS number: 615-20-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles. Study acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
- Principles of method if other than guideline:
- no guideline reported
single i.p. application to mouse, observation period 2 weeks - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorobenzothiazole
- EC Number:
- 210-415-0
- EC Name:
- 2-chlorobenzothiazole
- Cas Number:
- 615-20-3
- Molecular formula:
- C7H4ClNS
- IUPAC Name:
- 2-chloro-1,3-benzothiazole
- Details on test material:
- no purity specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further details reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- undiluted 2-Chlorobenzothiazole or 10 % w/v in corn oil
- Doses:
- 10, 50, 100, 3200 mg/kg bw
- No. of animals per sex per dose:
- 2 + 2 (16 animals in total)
- Control animals:
- not specified
- Details on study design:
- single application, observation period 14 d
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 - 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: time of death 2 h - 2 d
- Mortality:
- at highest dose time to death = 2h
- Clinical signs:
- quite to very weak:
- rough fur
- vasoconstriction and/or cyanosis - Body weight:
- increased during observation period
- Gross pathology:
- histopathological examination:
- chronic pneumonitis (in 10 mg/kg bw and 50 mg/kg bw groups)
- focal chronic interstititial nephritis ( in 1 out of 2 animals of the 10 mg/kg bw group)
- hydronephrosis ( in 1 out of 2 animals of the 3200 mg/kg bw group)(details not given)
- mild degree of hemosiderosis of the liver ( in 2 out of 2 animals of the 10 mg/kg bw group)
- moderately to severe liver necrosis ( in 2 out of 2 animals of the 3200 mg/kg bw group)
Applicant's summary and conclusion
- Conclusions:
- The LD50 (rat) is 50 - 100 mg/kg bw, applied i.p.
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