Registration Dossier
Registration Dossier
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EC number: 210-415-0 | CAS number: 615-20-3
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1958
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of certain benzimidazoles and reated compunds upon azo dye destraction by liver homogenates
- Author:
- Clayton S.C.
- Year:
- 1 958
- Bibliographic source:
- Proc. Soc. Exp. Biol. Med. 97, 510-512
Materials and methods
- Principles of method if other than guideline:
- Assay on the effect of 2-Chlorobenzothiazole on the activities of azo dye degrading enzymes in rat liver homogenates
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: Effect on enzymes enabling azo dye degradation
Test material
- Reference substance name:
- 2-chlorobenzothiazole
- EC Number:
- 210-415-0
- EC Name:
- 2-chlorobenzothiazole
- Cas Number:
- 615-20-3
- Molecular formula:
- C7H4ClNS
- IUPAC Name:
- 2-chloro-1,3-benzothiazole
- Details on test material:
- no purity specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- liver homgenates
Administration / exposure
- Route of administration:
- other: in vitro test
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 min
- Frequency of treatment:
- not relevant
- Post exposure period:
- not required
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mg 2-Chlorobenzothiazole/ 3 mL of reaction mixture
Basis:
nominal conc.
- No. of animals per sex per dose:
- not applicable
- Control animals:
- no
- Details on study design:
- In vitro test: control animals not required because enzyme test is calibrated with blancs and standardized solutions
Results and discussion
Any other information on results incl. tables
In the presence of 2 -Chlorobenzothiazole (1 mg/3 mL) in the reaction mix, the degradation of 4 -Dimethylaminoazobenzene, which was used to monitor the potential of rat liver homogenates to metabolize azo dyes, was inhibited by approximately 80 %.
Applicant's summary and conclusion
- Conclusions:
- 2-Chlorobenzothiazole (slightly) inhibits the degradation of the azo dye 4 -Dimethylaminoazobenzene in rat liver homogenates
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