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Diss Factsheets

Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
ECOSAR Program (v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: earthworm
Animal group:
other: QSAR model
Study type:
other: QSAR
Substrate type:
other: QSAR
Limit test:
no
Total exposure duration:
14 d
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Moisture:
not applicable. QSAR model
Details on test conditions:
100% sodium O-isobutyl dithiocarbonate
SMILES : O(C(CC)C)C(S([Na]))=S
CHEM : Carbonodithioic acid, o-(2-methylpropyl) ester, sodium salt
CAS Num: 25306-75-6
MOL FOR: C5 H9 O1 S2 Na1
MOL WT : 172.24
Log Kow: 1.78 (used)
Wat Sol: 663 mg/L (measured)
Reference substance (positive control):
no
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
315.602 mg/kg soil ww
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Details on results:
LC50 (14-day, earthworm)= 315.602 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=315.602 mg/kg soil dw
Reported statistics and error estimates:
US EPA accepted QSAR method for chemicals properties assessment.

Overview of QSARs estimations on toxicity of   SIBX to soil macroorganisms

Method

 

Results

Remarks

Reference

QSAR

estimate

LC50 (14-day, earthworm)= 315.602 mg/L (ppm)

 

 

Reliable withrestrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

LC50 (14-day, earthworm)= 315.602 mg/L (ppm)

 

 

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
LC50 (14-day, earthworm)= 315.602 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 315.602 mg/kg soil dw
Executive summary:

The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 315.602 mg/L (ppm).

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

LC50 (14-day, earthworm)= 315.602 mg/kg soil dw 

Description of key information

The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 315.602 mg/L (ppm). 
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same. 
LC50 (14-day, earthworm)= 315.602 mg/kg soil dw 

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:
315.602 mg/kg soil dw
Long-term EC10, LC10 or NOEC for soil macroorganisms:
63.1 mg/kg soil dw

Additional information

The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm)would to be 315.602mg/L (ppm).

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

LC50 (14-day, earthworm)= 315.602 mg/kg soil dw