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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR model
Principles of method if other than guideline:
EPI Suite v 4.0/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable. QSAR model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
other: Daphnid species
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Nominal and measured concentrations:
not applicable. QSAR model
Details on test conditions:
sodium O-isobutyl dithiocarbonate
SMILES : O(C(CC)C)C(S([Na]))=S
CHEM : Carbonodithioic acid, o-(2-methylpropyl) ester, sodium salt
CAS Num: 25306-75-6
MOL FOR: C5 H9 O1 S2 Na1
MOL WT : 172.24
Log Kow: 1.78 (used)
Wat Sol: 663 mg/L (measured)

Reference substance (positive control):
not required
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
113.157 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 113.157 mg/l therefore that the substance is effectively not toxic to Daphnid.

Overview of QSARs estimations on short-term aquatic toxicity of  SIBX to Daphnid     

Method

 

Results

Remarks

Reference

QSAR

estimate

Daphnid , 48-hr LC50 =113.157 mg/L (ppm)

 

Daphnid, 30-day, ChV (chronic value) =12.669 mg/L (ppm)

 

 

Reliable with restrictions,

QSAR estimateddata

ECOSAR Program (v1.00)

 

 

The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 113.157 mg/l therefore that the substance is effectively not toxic to Daphnid.

 

 Daphnid , 48-hr LC50 = 113.157 mg/L (ppm)

Daphnid, 30-day, ChV (chronic value) =12.669 mg/L (ppm)

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 113.157 mg/l therefore that the substance is effectively not toxic to Daphnid.
Executive summary:

The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 113.157 mg/l therefore that the substance is effectively not toxic to Daphnid.

  

 Daphnid , 48-hr LC50 = 12.669 mg/L (ppm)

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR model
Principles of method if other than guideline:
EPI Suite v 4.0/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable. QSAR model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
other: Mysid shrimp
Details on test organisms:
Scientific name: Americamysis bahia
Common name: Opossum shrimp, Mysid shrimp, Mysids
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Nominal and measured concentrations:
not applicable. QSAR model
Details on test conditions:
100% sodium O-isobutyl dithiocarbonate
SMILES : O(C(CC)C)C(S([Na]))=S
CHEM : Carbonodithioic acid, o-(2-methylpropyl) ester, sodium salt
CAS Num: 25306-75-6
MOL FOR: C5 H9 O1 S2 Na1
MOL WT : 172.24
Log Kow: 1.78 (used)
Wat Sol: 663 mg/L (measured)
Reference substance (positive control):
not required
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
241.858 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be 241.858 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.

Overview of QSARs estimations onshort-term aquatic toxicity of SIBX to Mysid shrimp   

Method

 

Results

Remarks

Reference

QSAR

estimate

Mysid Shrimp, 96 -hr, LC50= 241.858 mg/L (ppm)

Mysid Shrimp (SW), 30-day, ChV (chronic value) = 22.314 mg/L (ppm)

 

 

Reliable with restrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

Mysid Shrimp, 96 -hr, LC50= 241.858 mg/L (ppm)

Mysid Shrimp (SW), 30-day, ChV (chronic value) = 22.314 mg/L (ppm)

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be  241.858 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.
Executive summary:

The ECOSAR QSAR model predicts that LC50 for fresh water species cited would to be  241.858 mg/l therefore that the substance is effectively not toxic to Mysid shrimp.

 

 

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
24 h
Hardness:
NR
Test temperature:
20 °C
pH:
8.4
Dissolved oxygen:
O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm.
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3600 NR TO NR 3600 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3600 NR TO NR 3600 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
no
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
3.6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC10
Effect conc.:
1.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
other: EC95
Effect conc.:
11 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile

ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE
Validity criteria fulfilled:
yes
Conclusions:
A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
SIBX are related compound to SIPX.This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
24 h
Hardness:
NR
Test temperature:
20 °C
pH:
8.4
Dissolved oxygen:
O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm.
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3700 NR TO NR 3700 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3700 NR TO NR 3700 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
no
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
3.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC10
Effect conc.:
1.9 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
other: EC95
Effect conc.:
10 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile

ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE
Validity criteria fulfilled:
yes
Conclusions:
A 24 h EC50 of 3.7 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
SIBX are related compound to sodium O-sec-butyl dithiocarbonate
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 850.1020 (Gammarid Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Gammarus sp.
Details on test organisms:
SPECIES #
(NAME): 118 Gammarus sp. (Scud, Amphipod)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
118 to 125 mg/L CaCO3
Test temperature:
10 0C
pH:
7.9 to 8.2
Dissolved oxygen:
> 1 mg/L
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 8500 NR TO NR 8500 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter


TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 8500 NR TO NR 8500 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR


Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
8.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE: NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
Validity criteria fulfilled:
yes
Conclusions:
A 96 h LC50 of 8.5 mg/L has been determined for the effects of the test substance on mortality of the Gammarus sp.
(Scud, Amphipod).
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
SIBX are related compound to PAX.This paper focused mainly on the effects of xanthates on duckweed, and did not have a lot of details on the Daphnia bioassay. However, as some important experimental parameters were reported, the overall score isn’t too far from 70%, and a standard OECD method was used, this paper has been given a satisfactory reliability rating.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
SPECIES #
(NAME): 5 Daphnia magna (Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
24 h
Hardness:
NR
Test temperature:
20 °C
pH:
8.4
Dissolved oxygen:
O2-concentration was 9.8 mg/L,
conductivity was 325 µS/cm.
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3000 NR TO NR 3000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 24 hour(s)
STAND DUR. (D): 1 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 3000 NR TO NR 3000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 20 NR TO NR C
pH: 8.4 NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR mg/L CaCO3
CONDUCTIVITY: 325 NR TO NR µS/cm
DISSOLVED OXYGEN: 9.8 NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
no
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC10
Effect conc.:
1.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
other: EC95
Effect conc.:
6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
EFFECT RESULTS
EFFECT:Intoxication
TREND:NR
RESPONSE SITE:NR
% EFFECT:NR
EFFECT MEASUREMENT:Immobile

ENDPOINT: Effective concentration to 50% of test organisms
ENDPOINT ASSIGN.:X
SIGNIFICANCE: NA
LEVEL:NA
BCF Value (F): NR ( NR to NR
OTHER EFFECTS: EC10-95, FATE
Validity criteria fulfilled:
yes
Conclusions:
A 24 h EC50 of 3 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
SIBX are related compound to PEX
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 850.1020 (Gammarid Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Gammarus sp.
Details on test organisms:
SPECIES #
(NAME): 118 Gammarus sp. (Scud, Amphipod)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
118 to 125 mg/L CaCO3
Test temperature:
10 0C
pH:
7.9 to 8.2
Dissolved oxygen:
> 1 mg/L
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F 52000 NR TO NR 52000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter


TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 52000 NR TO NR 52000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR


Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
52 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE: NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
Validity criteria fulfilled:
yes
Conclusions:
A 96 h LC50 of 52 mg/L has been determined for the effects of the test substance on mortality of the Gammarus sp.
(Scud, Amphipod).
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide is both a reagent in the manufacture, as well as a decomposition product of xanthates. SIBX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SIBX. Incubation carried out in sealed vessels due to volatility of CS2.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
incubation in sealed vessels due to volatility of CS2
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
- Stock solution were prepared fresh each day.
- Test solutions were renewed daily.
Test organisms (species):
Daphnia magna
Details on test organisms:
SPECIES #
(NAME): 5 Daphnia magna
(Water Flea)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: Food: Chlorella pyrenoidosa
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
225 mg CaCO3/L
Test temperature:
20 °C
pH:
8.1
Dissolved oxygen:
Not reported
Salinity:
Not reported
Nominal and measured concentrations:
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGE STANDARD CONC (ug/L) ION
F 2100 1900 TO2200 2100 (1900-2200) ug/L NR
Details on test conditions:
Tests were carried out in sealed vessels to prevent evaporation of CS2.
The complete compostion of the test medium is given in Van Leeuwen and Maas, Environ. Pollution A37: 105-115 (1985).
Daphnids were fed with algal cells (Chlorella pyrenoidosa), 1E5 cells/mL.
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.1 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Remarks on result:
other: 95% C.I.: 1.9 - 2.2 mg/L
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
4.75 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: On a molecular weight scaled basis, the EC50 would be 4.75 mg/l. (2.1 x 172.24) /76.13 =4.75 mg/l
Details on results:
Sodium isobutyl xanthate readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of sodium isobutyl xanthate.
On a molecular weight scaled basis, the EC50 would be 4.75 mg/l.
(2.1 x 172.24) /76.13 =4.75 mg/l
Validity criteria fulfilled:
yes
Conclusions:
The 48-h EC50 for Daphnia magna in a sealed system was 2.1 mg /L.
Sodium isobutyl xanthate readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of sodium isobutyl xanthate.
On a molecular weight scaled basis, the EC50 would be 4.75 mg/l.
(2.1 x 172.24) /76.13 =4.75 mg/l
.
Executive summary:

Sodium isobutyl xanthate readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of sodium isobutyl xanthate.

On a molecular weight scaled basis, the EC50 would be 4.75 mg/l.

(2.1 x 172.24) /76.13 =4.75 mg/l

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Sodium hydroxide is both reagents used in the manufacture of sodium O-isobutyl dithiocarbonate . Therefore, sodium hydroxide need to be considered in the assessment of sodium O-isobutyl dithiocarbonate
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Crangon crangon
Details on test organisms:
SPECIES #
(NAME): 11 Crangon crangon (Common Shrimp, Sand Shrimp)
AGE: NR NR
LIFE STAGE: adult(s)
Test type:
semi-static
Water media type:
saltwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
NR
Test temperature:
15 0C
pH:
NR
Dissolved oxygen:
NR
Salinity:
NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
T NR 33000 TO 100000 33000-100000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: SW (Salt water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: R ( semi-static)
APPLICATION FREQ.: NR
EXPOSURE DUR.: 48 hour(s)
STAND DUR. (D): 2 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter


TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
T NR 33000 TO 100000 33000-100000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 15 NR TO NR C
pH: NR NR TO NR
HARDNESS: NR NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: NR NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR


Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
33 - 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE: NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality
ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
Validity criteria fulfilled:
yes
Conclusions:
A 48 h LC50 of 33 to 100 mg/L (saltwater) has been determined for the effects of the test substance on mortality of the Crangon crangon
(Common Shrimp, Sand Shrimp)

Description of key information

A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.
A 48 h LC50 of 33 to 100 mg/L (saltwater) has been determined for the effects of the test substance on mortality of the Crangon crangon
(Common Shrimp, Sand Shrimp)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.6 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
33 mg/L

Additional information

A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.

A 48 h LC50 of 33 to 100 mg/L (saltwater) has been determined for the effects of the test substance on mortality of the Crangon crangon (Common Shrimp, Sand Shrimp)