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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
SIBX are related compound to SEX

Data source

Reference
Reference Type:
publication
Title:
Metabolism of xanthates in man and guinea pig
Author:
Merlevede E and Peters J
Year:
1965
Bibliographic source:
Archives of the Belgian Medical Society, 23(8): 513-551

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium O-ethyl dithiocarbonate
EC Number:
205-440-9
EC Name:
Sodium O-ethyl dithiocarbonate
Cas Number:
140-90-9
Molecular formula:
C3H6OS2.Na
IUPAC Name:
sodium O-ethyl dithiocarbonate
Test material form:
solid: compact
Details on test material:
- Name of test material (as cited in study report):sodium ethyl xanthate

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Doses:
70-200 mg/kg of potassium ethyl xanthate
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: elimination of CS2
Effect level:
> 70 - < 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximum elimination between 1 - 2 h in most animals.
Sex:
not specified
Dose descriptor:
other: elimination of CS2
Effect level:
> 50 - < 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h

Any other information on results incl. tables

Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximumelimination between 1 - 2 h in most animals. The rate of elimination was doserelated,however the total percentage recovered was independent of dose. A morerapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, withmaximum elimination at 1 h (total recovery of CS2 was not reported).

Applicant's summary and conclusion

Conclusions:
Following sub-cutaneous injection (70-200 mg/kg) of potassium ethyl xanthate in guinea pigs, up to 7% of the dose was expired as CS2 after 8 h, with maximum elimination between 1 - 2 h in most animals. The rate of elimination was dose related, however the total percentage recovered was independent of dose. A more rapid rate of elimination was seen following sub-cutaneous injection (50 and 100mg/kg) of sodium ethyl xanthate, with CS2 expiration complete after 6 h, with maximum elimination at 1 h (total recovery of CS2 was not reported).