Registration Dossier
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EC number: 212-090-0 | CAS number: 761-65-9
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
It can be concluded that adsorption of N,N-dibutylformamide (CAS 761 -65 -9) to the solid soil phase is not to be expected under environmentally relevant conditions.
Key value for chemical safety assessment
- Koc at 20 °C:
- 22.7
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of the N,N-dibutylformamide (CAS 761-65-9) (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the adsorption potential are not provided.
Assessment
In accordance with column 2 of REACH Annex IX the study does not need to be conducted since the substance has a log Kow less or equal than 3. N,N-Dibutylformamide has a log Kow of 2 (measured, BASF SE, 2017, report no. 17L00358).
In order to assess the substance’s adsorption potential, the Koc value was estimated using (Q)SAR models. According to the MCI method of the KOCWIN v2.00 module of EPI Suite v4.11, the substance has a Koc of 22.7 L/kg (log Koc = 1.36). The MCI module is more reliable than the KOW method of KOCWIN v2.00, which estimates the Koc based on the log Kow; therefore, the result from the MCI model was used as key study. However, both models resulted in very similar adsorption coefficients. The KOW method resulted in a Koc of 58.1 L/kg, based on the estimated log Kow of 2.01 (KOWWIN v1.68, EPI Suite v4.11). The substance is in the applicability domain of both models.
It can be concluded that adsorption to the solid soil phase is not to be expected under environmentally relevant conditions.
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