Registration Dossier
Registration Dossier
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EC number: 212-090-0 | CAS number: 761-65-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The substance is acutely not harmful to algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 483.7 mg/L
- EC10 or NOEC for freshwater algae:
- 111 mg/L
Additional information
The toxicity of the test substance to aquatic algae and cyanobacteria was assessed in a study under static conditions according to the DIN 38412 L9 (similar to OECD 201). The nominal test concentrations were 25, 50, 100 and 250 mg/L; in addition, the substance is assumed to be stable. The Substance has a water solubility of 11.8 g (BASF SE, 2017, report no.: 17L00357). The substance appears in the uncharged form under environmentally relevant conditions (pKa = -1.2, SPARC Online Calculator, BASF SE, 2017). Adsorption is not expected based on the low log Kow (log Kow = 2, at pH 6, measured, BASF SE, 2017, rep. no.: 17L00358) and log Koc (log Koc = 1.36; estimated for the uncharged molecule; BASF SE, 2017). The Substance has a low Henry's Law Constant (HLC = 0.041 Pa m³/mol, 25 °C, estimated, BASF SE, 2017). The substance has also a moderate vapor pressure (VP = 4.22 Pa @25°C, calculated with EPI Suite v4.11, BASF SE 2017).
The data of the original report were re-evaluated using ToxRat v3.3 in order to obtain an EC10 for the test period of 72 h, which is originally not reported. Additionaly the reliable validity criteria were checked. According to REACH Guidance document chapter R.10 Table R.10-1 (Overview of toxicity test endpoints and guidance on derivation of L(E)C50 and NOEC values) an EC10 for a long-term test which is obtained using an appropriate statistical method (usually regression analysis) will be used preferentially.
A 72 -h ErC50 of 483.7 mg/L (nominal, 95% CL: 426.8 – 569.5 mg/L) and a 72 -h ErC10 of 111 mg/L (nominal, 95% CL: 97.8 – 122.5 mg/L) were determined (BASF AG, 1989; recalculated, BASF SE, 2021)
In conclusion, the substance is assessed to be acutely not harmful to algae.
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