Registration Dossier
Registration Dossier
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EC number: 212-090-0 | CAS number: 761-65-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to H.F. Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95 - 107 (1962)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- N,N-dibutylformamide
- EC Number:
- 212-090-0
- EC Name:
- N,N-dibutylformamide
- Cas Number:
- 761-65-9
- Molecular formula:
- C9H19NO
- IUPAC Name:
- N,N-dibutylformamide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 194 g, females 163 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- 0.2 mg/L
- No. of animals per sex per dose:
- 12 (sex not specified)
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology: heart, lung, trachea, liver, spleen, kidney, central nervous system, lymph node system
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- discriminating conc.
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: saturated atmosphere
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- Nothing abnormal detected.
- Other findings:
- - Histopathology: No findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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