Registration Dossier
Registration Dossier
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EC number: 283-381-8 | CAS number: 84604-96-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- may - june 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis[bis(3,5,5-trimethylhexyl)dithiocarbamate-S,S']zinc
- EC Number:
- 283-381-8
- EC Name:
- Bis[bis(3,5,5-trimethylhexyl)dithiocarbamate-S,S']zinc
- Cas Number:
- 84604-96-6
- Molecular formula:
- C38H76N2S4Zn
- IUPAC Name:
- bis({[bis(3,5,5-trimethylhexyl)carbamothioyl]sulfanyl})zinc
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- purity 98%
white powder
stored at ambient temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Remarks:
- 50 % w/v in 1% methyl cellulose
- Details on oral exposure:
- dose was administered at a volume not exceeding 10ml/kg
- No. of animals per sex per dose:
- 5 animals per sex
- Details on study design:
- Animals observed soon after dosing, then at frequent intervals for remainder of day 1. All animals were observed for 14 days after dosing
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- two female rats treated at 5g/kg/bw died from within 91 to 115 hours after dosing.
- Clinical signs:
- other: Pilo erection, abnormal gait, increased salivation and lethargy was seen in all treated animals. recovery was judged by external appearance and behaviour- apparent by day 9
- Gross pathology:
- Autopsy of two deceased female rats, revealed congestion of the lungs, and pallor of the liver, spleen, kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Acute oral LD50 > 5g/kg/bw
- Executive summary:
none classified for oral toxicity based on study OECD 401
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