Bis[bis(3,5,5-trimethylhexyl)dithiocarbamate-S,S']zinc

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics, other

Type of information:

other: assessment of physchem/ potential metabolic pathway

Adequacy of study:

key study

Applicant's summary and conclusion

Conclusions:

Chemical structure of Zinc diisonoyl dithiocarbamate has main functional group associated with dithiocarbamates, structural functional groups include a Zinc ion with two diisononylamine dithiocarbamate ligands and exists in a divalent and tetravalent form

Relevant physicochemical properties :
)Molecular weight : 745g/mol or Da
Physical form : free flowing powder with mean aerodynamic diameter of 25µm (D50)
Vapour pressure : 8.5 X 10 -4 Pa at 25°C Low vapour pressure
Water solubility : 0.6 mg/l (poorly water soluble)
LogKow : >6.5 Hplc method
Hydrolysis TBD- testing underway
pH 9 ( 10% aq solution- distilled water)
pKa 3.4 ( relaible QSAR)

Absorption
pKa 3.4 – therefore Arbestb Z is largely unionised in stomach and ionised in intestines. We would therefore expect absorption of parent to occur in stomach & minimal parent absorption in intestine
Main routes are inhalation of dust, but dermal absorption is unlikely due to high molecular weight, greater than 500 Da
Absorption is evident with haemtological effects observed in repeat dose studies

Metabolism
Arbestab Z is likely to be metabolised in liver into dialkyldithiocarbamic acid or as a S-glucuronide conjugate with further metabolism to dialkylamine and carbon disulphide as most dithiocarbamates

Distribution
general absorbed dithiocarbamates can be found in following organs, liver, kidneys and thyroid gland, but accumulation of these compounds does not take place because of rapid metabolism.

Elimination
The biotransformation of dithiocarbamates in phase two conjugation with polar/hydrophillic glucuronide results in principle excretion via kidneys.

Executive summary:

Physchemical properties show the test item will undergo rapid metabolism