Sodium O-isobutyl dithiocarbonate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Remarks:

Note that in-vivo eye irritation should not have been attempted in view of results of in-vivo skin irritation. These historical data are included for information only

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Justification for type of information:

Study provided on similar substance to help build up a weight of evidence demonstrating potential for read-across between the xanthates
Note that in-vivo eye irritation should not have been attempted in view of results of in-vivo skin irritation. These historical data are included for information only

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium O-isobutyl dithiocarbonate

EC Number:

246-805-2

EC Name:

Sodium O-isobutyl dithiocarbonate

Cas Number:

25306-75-6

Molecular formula:

C5H10OS2.Na

IUPAC Name:

sodium [(2-methylpropoxy)methanethioyl]sulfanide

Constituent 2

Reference substance name:

Sodium isobutyl xanthate

IUPAC Name:

Sodium isobutyl xanthate

Test material form:

other: water solution

Test animals / tissue source

Species:

rabbit

Test system

Vehicle:

water

Amount / concentration applied:

0.1 ml/eye as water solution pH=10.1, containing 456,1g/dm3 of the substance

Duration of treatment / exposure:

introduced into the conjunctival sacs of the right eye

Observation period (in vivo):

Observation were made after 1h, 24, 48 hours and then after 7 days

Number of animals or in vitro replicates:

1 male

Details on study design:

introduced into the conjunctival sacs of the right eye

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

24 h

Score:

3

Max. score:

3

Reversibility:

not reversible

Remarks on result:

probability of severe irritation

Results 2

Irritation parameter:

other: IIPO

Time point:

other: 7

Score:

110

Reversibility:

not fully reversible within:

Remarks on result:

probability of severe irritation

Results 3

Irritation parameter:

other: IIPO

Time point:

other: 1-48 h

Score:

77.7

Reversibility:

not fully reversible within:

Remarks on result:

probability of severe irritation

Irritant / corrosive response data:

After 1h, ¾ of the cornea surface was clouded,in the iris was noted congestion. The conjunctiva was reddened, red beet color, oedema, and discharge on palpebra. After 24h and 48h the changes in eye became more intense, pupil was visible in lower part of the eye, details of iris was not visible, the pupil reacted slowly on light. After 7 days changes in the eye became more intense, ¾ of cornea was clouded, in lower part of the cornea details of iris was not visible. In the cojunctiva of the lower palpebra necrosis was noted.
NOTE : This study should have been terminated immediately

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Conclusions:

Sodium isobutyl xanthate should be consider as seriously injured substance of the rabbit eyes.

Executive summary:

Study provided on similar substance to help build up a weight of evidence demonstrating potential for read-across between the xanthates

Note that in-vivo eye irritation should not have been attempted in view of results of in-vivo skin irritation.  These historical data are included for information only