Sodium O-isobutyl dithiocarbonate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Ma

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

not specified

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Proxan-sodium

EC Number:

205-443-5

EC Name:

Proxan-sodium

Cas Number:

140-93-2

Molecular formula:

C4H8OS2.Na

IUPAC Name:

sodium O-isopropyl dithiocarbonate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

The method of Noakes and Sanderson was used. Groups of rats of each sex, aged 12-13 weeks, were used at each dose level. The test material was placed onto the shorn dorsa-lumbar skin and bandaged into contact with the skin using an impermeable dressing of aluminium foil and waterproof plaster.

Duration of exposure:

24 hours

Doses:

1000 mg/kg

No. of animals per sex per dose:

4 male, 4 female

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 000 mg/kg bw

Based on:

test mat.

Mortality:

I animal died (female)

Clinical signs:

other: There was no toxic reaction in the surving animals.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 via the dermal route in rats was greater than 1000 mg/L.