Registration Dossier
Registration Dossier
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EC number: 246-805-2 | CAS number: 25306-75-6
Endpoint summary
Administrative data
Description of key information
Testing of xanthates by animal or non-animal metods is not considered possible.
Animal testing is not permitted on corrosive or strongly irritant substances
In-vitro methods rely on aqueous test systems and the substance will rapidly hydrolyse to alcohol and carbon disulphide.
In-vitro assessments have been performed and these give a strong prediction for positive skin sensitisation. It is proposed to classifiy as Skin Sens 1.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Remarks:
- Estimation
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- Skin Sensitization Test compatible with OECD429 guidance.The final conclusion is a conclusion made by the reviewer, taking into account all the available evidence, including the in-silico and available experimental results.
- GLP compliance:
- no
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
Reference
The final conclusion is that the tested sodium O-ethyl dithiocarbonate (CAS# 140-90-9) is considered to be threatening to humans from this evaluation.
The probability that the prediction is accurate is 80%.
The compound is predicted to be VERY active.
The projected sensitization activity is 55.0 CASE units.
Case units: active = 30 – 80; inactive = 10 – 19; marginal = 20 – 29 .
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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