Registration Dossier
Registration Dossier
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EC number: 246-805-2 | CAS number: 25306-75-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Full Public Report Sodium Ethyl Xanthate Priority Existing Chemical No. 5
- Author:
- Australian Government Publishing Service Canberra
- Year:
- 1 995
- Bibliographic source:
- Australian Government Publishing Service Canberra
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium O-pentyl dithiocarbonate
- EC Number:
- 220-329-5
- EC Name:
- Potassium O-pentyl dithiocarbonate
- Cas Number:
- 2720-73-2
- Molecular formula:
- C6H12OS2.K
- IUPAC Name:
- potassium O-pentyl dithiocarbonate
- Reference substance name:
- Potassium amyl xanthate
- IUPAC Name:
- Potassium amyl xanthate
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
Constituent 1
Constituent 2
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 30-day
- Frequency of treatment:
- 6 hrs daily, 5 days a week for a total of 20 exposures in 1 month
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:100 mg/m3Basis:nominal conc.
- Remarks:
- Doses / Concentrations:800 mg/m3Basis:nominal conc.
- No. of animals per sex per dose:
- 2
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- LOEC
- Effect level:
- 100 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Hepatotoxic effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The results of this study indicate that potassium amyl xanthate has an adverse effect on the the liver in dogs. There were no treatment-related changes in the haematological or urinalysis values in any of the animals.
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