Registration Dossier
Registration Dossier
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EC number: 930-915-9 | CAS number: 1318-02-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- other: data from report on workplace safety
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Biochemistry
- Author:
- Berg JM, Tymoczko JL, Stryer L
- Year:
- 2 002
- Bibliographic source:
- WH Freeman, New York
- Reference Type:
- review article or handbook
- Title:
- Zeolithe, synthetisch, nicht faserförmig
- Author:
- MAK commission
- Year:
- 2 014
- Bibliographic source:
- MAK, 56. Lieferung, 2014
Materials and methods
Test material
- Reference substance name:
- Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- EC Number:
- 930-915-9
- Cas Number:
- 1318-02-1
- Molecular formula:
- M2/nO • Al2O3 • ySiO2 • wH2O (n is the valency of the cation M, predominantly Na, y can range from 0.64 to 8.8, and w is the number of water molecules (general formula) Na: 1.34 - 24.02%, Al: 2.20 - 39.51%, Si: 15.52 - 68.64% (general composition); additionally, depending on the water quality: Ca, Mg and K might be present below 6%
- IUPAC Name:
- Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- Test material form:
- solid: particulate/powder
- Remarks:
- no surface treatment
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No dermal absorption is known. Because of their poor solubility in water and their ionic character, it can be assumed that zeolites cannot penetrate the intact skin.
- Executive summary:
Zeolite particles are absorbed by inhalation and orally. No dermal absorption is known. Because of their poor solubility in water and their ionic character, it can be assumed that zeolites cannot penetrate the intact skin. Since zeolites can easily absorb positively charged metal ions due to their structure and crystal structure, calcium could also be absorbed. There is no known evidence that the intracellular calcium concentration is significantly impaired if a portion of the extracellular calcium ions is absorbed after exposure to zeolite. The extracellular calcium concentration is very high compared to the intracellular concentration, and the intracellular calcium concentration becomes strictly regulated (Berg et al. 2002).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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