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Environmental fate & pathways

Hydrolysis

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Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb. 18, 2021 - Jan. 24, 2022; experimental phase: Apr. 12 - 21, 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
Apr. 13, 2004
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Name: Zeocros CG180 (P Zeolite)
Batch no.: 2020-531
Appearance: off-white powder
Composition: Zeolite (crystalline Aluminium silicate) 95-100%
CAS No.: 1318-02-1
EC-No.: not stated
Molecular formula: not stated
Molecular weight: not stated
Purity: not applicable, UVCB
Homogeneity: homogeneous
Production date: Dec. 2020
Expiry date: 01. Jan. 2022
Storage: room temperature (20 ± 5 °C)
Stability: stable under storage conditions
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Buffer-Solution, pH 4:
CH3COOH, 2 M: 160 mL
CH3COONa, 1 M: 80 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 7:
KH2PO4: 17.4170 g
Water p.a.: 1000 mL
NaOH, 2 M: 29.8 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 9:
Tris 0.1 M: 1000 mL
HCl 0.1 M: 160 mL
Water p.a.: ad. 2000 mL

Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
50 g/L
Number of replicates:
2 per pH level
Negative controls:
yes
Remarks:
blank controls: 1 per pH level
Statistical methods:
The mean concentrations of two replicates were used for calculation of stability.
Preliminary study:
As the amounts of Si and Al after five days were more than 90% of the amounts at the start of the test in pH 4 and 7 buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Transformation products:
no
% Recovery:
24.5
St. dev.:
7
pH:
9
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
92.4
St. dev.:
2.6
pH:
7
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
93.3
St. dev.:
4.9
pH:
4
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
100
St. dev.:
0.3
pH:
7
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
100
St. dev.:
0.8
pH:
4
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
The amounts of Si and Al in all buffer solutions after five days were more than 90% of the amount at the start of the test except the amount of Al in pH 9 buffer solution (24.5 %). A precipitation of Al in pH 9 buffer solution during the storage may be a reason for the low value. The determination of undissolved particles in the pH 9 test item solution after 5 days was not possible as the LOD of Tyndall device was 3 mg/L particle concentration. As the concentration of Si in pH 9 buffer solution was < 0.3 mg/L, no evaluation was possible.

A precipitation of Al in pH 9 buffer solution during the storage may be a reason for the low value. A possible explanation for the low recovery: the particles behave very different than a liquid aerosol in the high energy plasma as they will remain solid and thus the adsorption and emission of the light is underestimating. The aluminium content of a particle remains as one solid system while the dissolved Al is wide dispersed. In conclusion, the determination of Al in pH 9 buffer solution is not possible due to a presence of undissolved particles.


The determination of undissolved particles in the pH 9 test item solution after 5 days was not possible as the LOD of Tyndall device was 3 mg/L particle concentration.

Validity criteria fulfilled:
yes
Conclusions:
As the amounts of Si and Al after five days were more than 90% of the amounts at the start of the test in pH 4 and 7 buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Executive summary:

The hydrolysis and stability of the dissolved test item Zeocros CG180 in dependence of the pH (4, 7 and 9) was determined by measurement of Silicon (Si) and Aluminium (Al) concentrations in ultrafiltrated test solutions with the nominal concentration 50 g/L (2-fold diluted in order to get the half-saturated concentrations). Potentially available undissolved particles in the filtrated test item solutions were measured using Tyndall device. As more than 90 % of Si and Al were found after the storage of solutions for 5 days at 50 °C, the preliminary test (Tier 1) for 5 days at pH 4, 7 and 50 °C was sufficient. The amount of Al in pH 9 buffer solution after five days was lower than 90% of the amount at the start of the test (24.5 %). A precipitation of Al in pH 9 buffer solution during the storage may be a reason for the low value. As the concentration of Si in pH 9 buffer solution was < 0.3 mg/L, no evaluation was possible.

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb 18, 2021 - Jan. 17, 2022; experimental phase: Mar. 15 - 23, 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
Apr. 13, 2004
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Name: SYLOSIV A4 (A Zeolite)
Batch no.: 1000361205
Appearance: off-white powder
Composition: Zeolite (crystalline Aluminium silicate) 95-100%
CAS No.: 1318-02-1
EC-No.: 215-283-8 (930-915-9)
Molecular formula: not stated
Molecular weight: not stated
Purity: not applicable, UVCB
Homogeneity: homogeneous
Production date: 01. Dec. 2020
Expiry date: 31. Jan. 2022
Storage: room temperature (20 ± 5 °C)
Stability: stable under storage conditions
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Buffer-Solution, pH 4:
CH3COOH, 2 M: 160 mL
CH3COONa, 1 M: 80 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 7:
KH2PO4: 17.4170 g
Water p.a.: 1000 mL
NaOH, 2 M: 29.8 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 9:
Tris 0.1 M: 1000 mL
HCl 0.1 M: 160 mL
Water p.a.: ad. 2000 mL

Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
50 g/L
Number of replicates:
2 per pH level
Negative controls:
yes
Remarks:
blank controls: 1 per pH level
Statistical methods:
The mean concentrations of two replicates were used for calculation of stability.
Preliminary study:
As the amounts of Si and Al in all buffer solutions after five days were more than 90% of the amounts at the start of the test, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Transformation products:
no
% Recovery:
91.5
St. dev.:
8.4
pH:
9
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
100
St. dev.:
5.6
pH:
7
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
91.2
St. dev.:
2.4
pH:
4
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
98.6
St. dev.:
2.8
pH:
9
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
100
St. dev.:
0.4
pH:
7
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
99.4
St. dev.:
1.1
pH:
4
Temp.:
20.25 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
The measurement of the test item solutions for undissolved particles via Tyndall device showed the concentration < LOD (< 3 mg/L) of the particle concentrations.
Validity criteria fulfilled:
yes
Conclusions:
As the amounts of Si and Al after five days were more than 90% of the amounts at the start of the test in all buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Executive summary:

The hydrolysis and stability of the dissolved test item SYLOSIV A4 in dependence of the pH (4, 7 and 9) was determined by measurement of Silicon (Si) and Aluminium (Al) concentrations in filtrated test solutions with the nominal concentration 50 g/L (2-fold diluted in order to get the half-saturated concentrations). Potentially available undissolved particles in the filtrated test item solutions were measured using Tyndall device. As more than 90 % of Si and Al was found after the storage of solutions for 5 days at 50 °C, the preliminary test (Tier 1) for 5 days at pH 4, 7, 9 and 50 °C was sufficient.

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb. 18, 2021 - Jan. 17, 2022; experimental phase: Feb. 22 - Apr. 27, 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
Apr. 13, 2004
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Name: NA Y Zeolite (Y Zeolite)
Batch no.: RZ200094/1
Appearance: off-white powder
Composition: Zeolite (crystalline Aluminium silicate) 95-100%
CAS No.: 1318-02-1
EC-No.: 215-283-8 (930-915-9)
Molecular formula: not stated
Molecular weight: not stated
Purity: not applicable, UVCB
Homogeneity: homogeneous
Production date: 01. Dec. 2020
Expiry date: 31. Jan. 2022
Storage: room temperature (20 ± 5 °C)
Stability: stable under storage conditions
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Buffer-Solution, pH 4:
CH3COOH, 2 M: 160 mL
CH3COONa, 1 M: 80 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 7:
KH2PO4: 17.4170-17.4171 g
Water p.a.: 1000 mL
NaOH, 2 M: 29.8 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 9:
Tris 0.1 M: 1000 mL
HCl 0.1 M: 160 mL
Water p.a.: ad. 2000 mL

Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
50 g/L
Number of replicates:
2 per pH level
Negative controls:
yes
Remarks:
blank controls: 1 per pH level
Statistical methods:
The mean concentrations of two replicates were used for calculation of stability.
Preliminary study:
As the amounts of Si after five days were more than 90% of the amounts at the start of the test in all buffer solutions and Al in pH 4 and 7 buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Transformation products:
no
% Recovery:
96.5
St. dev.:
21.4
pH:
7
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
91.7
St. dev.:
3.7
pH:
4
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration - second measurement
% Recovery:
84.6
St. dev.:
1.9
pH:
4
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration - first measurement
% Recovery:
98.9
St. dev.:
7.9
pH:
9
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
98.4
St. dev.:
2.7
pH:
7
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
99.2
St. dev.:
0.6
pH:
4
Temp.:
20 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
The measurement of the test item solutions for undissolved particles via Tyndall device showed the concentration < LOD (< 3 mg/L) of the particle concentrations.

The repetition of the test in pH 4 buffer solution showed the concentration of Al > 90 % of initial value only. The result of the first determination was not used in the evaluation as during the measurement a fluctuation of the QC sample was observed resulting in an insufficient precision of the measurement.
Validity criteria fulfilled:
yes
Conclusions:
As the amounts of Si after five days were more than 90% of the amounts at the start of the test in all buffer solutions and Al in pH 4 and 7 buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Executive summary:

The hydrolysis and stability of the dissolved test item Na Y Zeolite in dependence of the pH (4, 7 and 9) was determined by measurement of Silicon (Si) and Aluminium (Al) concentrations in filtrated test solutions with the nominal concentration 50 g/L (2-fold diluted in order to get the half-saturated concentrations). Potentially available undissolved particles in the filtrated test item solutions were measured using Tyndall device. As more than 90% of Si and Al was found after the storage of solutions for 5 days at 50 °C, the preliminary test (Tier 1) for 5 days at pH 4, 7, 9 and 50°C was sufficient.

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb. 18, 2021 - Jan. 24, 2022; experimental phase: Mar. 26 - Apr. 14, 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Version / remarks:
Apr. 13, 2004
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Name: KÖSTROLITH NaMSXP-TR (X Zeolite)
Batch no.: 2006090001
Appearance: off-white powder
Composition: Zeolite (crystalline Aluminium silicate) 95-100 %
CAS No.: 1318-02-1
EC-No.: 215-283-8 (930-915-9)
Molecular formula: not stated
Molecular weight: not stated
Purity: not applicable, UVCB
Homogeneity: homogeneous
Production date: 24. Nov. 2020
Expiry date: 31. Jan. 2022
Storage room temperature (20 ± 5 °C)
Stability stable under storage conditions

Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Buffer-Solution, pH 4:
CH3COOH, 2 M: 160 mL
CH3COONa, 1 M: 80 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 7:
KH2PO4: 17.4170 g
Water p.a.: 1000 mL
NaOH, 2 M: 29.8 mL
Water p.a.: ad. 2000 mL

Buffer-Solution, pH 9:
Tris 0.1 M: 1000 mL
HCl 0.1 M: 160 mL
Water p.a.: ad. 2000 mL

Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
50 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
50 g/L
Number of replicates:
2 per pH level
Negative controls:
yes
Remarks:
blank controls: 1 per pH level
Statistical methods:
The mean concentrations of two replicates were used for calculation of stability.
Preliminary study:
As the amounts of Si and Al in all buffer solutions after five days were more than 90% of the amounts at the start of the test, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Transformation products:
no
% Recovery:
93.6
St. dev.:
2.4
pH:
9
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
99.7
St. dev.:
1.3
pH:
7
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
100
St. dev.:
11.9
pH:
4
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: aluminium concentration
% Recovery:
99.6
St. dev.:
0.7
pH:
9
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
94.3
St. dev.:
0.1
pH:
7
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
% Recovery:
95.6
St. dev.:
1.6
pH:
4
Temp.:
20.5 °C
Duration:
5 d
Remarks on result:
other: silicon concentration
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
The measurement of the test item solutions for undissolved particles via Tyndall device showed the concentration < LOD (< 3 mg/L) of the particle concentrations.
Validity criteria fulfilled:
yes
Conclusions:
As the amounts of Si and Al after five days were more than 90% of the amounts at the start of the test in all buffer solutions, the whole test item was considered to be stable (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examination was made.
Executive summary:

The hydrolysis and stability of the dissolved test item KÖSTROLITH NaMSXP-TR in dependence of the pH (4, 7 and 9) was determined by measurement of Silicon (Si) and Aluminium (Al) concentrations in ultrafiltrated test solutions with the nominal concentration 50 g/L (2fold diluted in order to get the half-saturated concentrations). Potentially available undissolved particles in the filtrated test item solutions were measured using Tyndall device. As more than 90 % of Si and Al was found after the storage of solutions for 5 days at 50 °C, the preliminary test (Tier 1) for 5 days at pH 4, 7, 9 and 50 °C was sufficient.

Description of key information

Four types of Zeolites were tested for hydrolysis. All four were hydrolytically stable.


As the amounts of Si and Al after five days were more than 90% of the amounts at the start of the tests in pH 4 and 7 buffer solutions, the whole test items were considered to be stable in preliminary tests (following OECD, t(0.5) at 25 °C is then greater than 1 year), and no further examinations were made.


A precipitation of Al in Zeocros CG180 pH 9 buffer solution during the storage may be a reason for the low value.

Key value for chemical safety assessment

Additional information