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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
The metabolism of tri-alkyl phosphates
Author:
Jones AR
Year:
1970
Bibliographic source:
Experimentia 26, 492

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
urine of rats and mice were examined for metabolites of 32P-triethylphosphate
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl phosphate
EC Number:
201-114-5
EC Name:
Triethyl phosphate
Cas Number:
78-40-0
Molecular formula:
C6H15O4P
IUPAC Name:
triethyl phosphate
Details on test material:
no further data
Radiolabelling:
yes
Remarks:
32P-triethylphosphate

Test animals

Species:
other: rats and mice
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: oral or intraperitoneal administration
Vehicle:
not specified
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 100 mg/kg bw (oral) or 1000 mg/kg bw (intraperitoneal)
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found.

Any other information on results incl. tables

The loss of the alkyl group in trialkyl phosphates is due both to enzymic hydrolysis (P-O cleavage) and de-O-alkylation (C-O cleavage), the latter being known to involve reduced gluthatione as acceptor.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case was the trialkyl-phosphate excreted unchanged.