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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Triethyl phosphate
EC Number:
201-114-5
EC Name:
Triethyl phosphate
Cas Number:
78-40-0
Molecular formula:
C6H15O4P
IUPAC Name:
triethyl phosphate

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Controls:
yes
Amount / concentration applied:
100 µl
Duration of treatment / exposure:
24 h
Observation period (in vivo):
21 d
Number of animals or in vitro replicates:
3, female

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
cornea opacity score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
cornea opacity score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Other effects:
see: remarks on results

Any other information on results incl. tables

Test for irritant effect on the eye (expos.24 h)


 
























































































































































































































































































































































































 Animal No: (body weight) tissue signs DRAIZE grades                   Irrit. index
    1h 24h 48h 72h 7d 14d 21d 
 D38, female (3,8 kg) cornea o 1 2 2 1 0 0 0 1,7
   a 4 4 4 40  0 0 
 fluorescein i - 1 2 1 0 - - 
   a - 4c 3c 2c 0 - - 
  iris  0 0 0 0 0 0 0 0,0
 conjunctivae r 0 2 2 2 0 0 0 2,0
   s 3 2 0 0 0 0 0 0,7
 aqueoushumour 0 0 0 0 0 0 0 0 
  discharge 3 3 2 2 0 0 0 0 
 F21, female(3,7 kg) cornea o 1 2 2 1 0 0 0 1,7
   a 4 4 4 4 0 0 0 
  fluorescein i - 1 1 1 0 - - 
   a - 4c 3c 1c 0 - - 
  iris  0 0 0 0 0 0 0 0,0
  conjunctivae r 0 2 2 2 0 0 0 2,0
   s 4 20  0 0 0 0 1,7
  aqueous humour  0 0 0 0 0 0 0 
  discharge  3 3 1 1 0 0 0 
 D33, female(3,6 kg) cornea o 1 2 2 1 1 1 0 1,7
   a 4 4 4 4 32  0 
  fluorescein i - 1 2 1 1 0 0 
   a - 3c 4c 4c1c  0 0 
  iris  0 0 0 0 0 0 0 0,0
  conjunctivae r 0 2 2 2 0 0 0 2,0
   s 3 0 0 0 0 0 0 0,0
  aqueous humour  0 0 0 0 0 0 0 
  discharge  3 3 1 1 0 0 0 

 


o = opacity


a = area


i = intensity


r = redness


s = swelling


- = not examined


c = confluent diffuse areas

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information
Executive summary:

The irritant effects of the test substance TEP were tested in an eye irritation study in rabbits in accordance with the OECD Guideline No. 405.

The substance was moderately irritating to the eye (exposure period: 24 hrs) with a mean conjuctivae score of 2.0.