Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Letter to US EP cited in BUA 37
- Author:
- Eastman Kodak Co
- Year:
- 1 984
- Bibliographic source:
- Doc ID 86-910000057 cited in BUA 37
- Reference Type:
- review article or handbook
- Title:
- Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)
- Author:
- Anon
- Year:
- 1 989
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)
Materials and methods
- Principles of method if other than guideline:
- Three groups of 5 male rats were exposed by inhalation to aerosol concentrations of 0, 366, or 1786 mg/m³ of the test substance 5 h/day, 5 days/week for a total of 12 exposures. About 35% of the test atmosphere was respirable.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- 5 h/day, 5 days per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 366, or 1786 mg/m³
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 366 mg/m³ air
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Abnormal clinical signs in the high-exposure group included lethargy, decreased aural response, unsteady gait, and porphyrin nasal discharges which resolved prior to subsequent exposures. No abnormal clinical signs were seen in the low-dose group. Weight gain, hematology, clinical chemistry, and gross and histopathology were unremarkable at both dose levels. Slightly increased (17 -19%) absolute and relative (to body weight) liver weights were noted in the high-exposure group, but these were not considered toxicologically significant in the absence of histopathology or clinical chemistry changes.
Applicant's summary and conclusion
- Executive summary:
Three groups of 5 male rats were exposed by inhalation to aerosol concentrations of 0, 366, or 1786 mg/m³ of the test substance 5 h/day, 5 days/week for a total of 12 exposures. About 35% of the test atmosphere was respirable.
A NOAEL = 366 mg/m³ was observed.
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