Registration Dossier
Registration Dossier
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EC number: 203-577-9 | CAS number: 108-39-4
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: special study with insufficient information
Data source
Reference
- Title:
- No information
- Author:
- Shelley WB (1974) p-cresol: cause of ink-induced hair depigmentation in mice. Brit J Dermatol 90: 169-174
Materials and methods
- Principles of method if other than guideline:
- 5 rats, application of the substance to depilated or clipped lower back by mist spray; observation of the hair colour of the new hair regrowth were made weekly.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- m-cresol
- Details on test material:
- no data on purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CBA/J
- Sex:
- female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 6 w
- Frequency of treatment:
- 3 times/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 % in acetone
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 6 months
Results and discussion
Results of examinations
- Details on results:
- see section "remarks on results"
Any other information on results incl. tables
No depigmentations of the regrowthed hair were observed.
Applicant's summary and conclusion
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