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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited documentation; no information on exposure time and conditions

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1969

Materials and methods

Principles of method if other than guideline:
0.5 ml undiluted TS was applied to the intact and to the abraded skin, time of observation: 24 and 72 hours
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-cresol
EC Number:
203-577-9
EC Name:
m-cresol
Cas Number:
108-39-4
Molecular formula:
C7H8O
IUPAC Name:
m-cresol
Details on test material:
m-Cresol, M.P.:11-12 C; B.P.: 202.8 C

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
other: partly shaved intact skin, partly shaved and abraded skin
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
no data undiluted
Observation period:
up to 72 hours
Number of animals:
6
Details on study design:
evaluation of erythema and edema

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 8
Max. score:
8
Reversibility:
not reversible
Remarks on result:
other: All animals showed erythema (score 4 of max.4) and edema (score 4 of max.4) from the first observtion time point being reported (24h).
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 4
Max. score:
4
Reversibility:
no data
Remarks on result:
other: All animals showed erythema (score 4 of max.4) and edema (score 4 of max.4) from the first observtion time point being reported (24h).
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
ca. 4
Max. score:
4
Reversibility:
no data
Remarks on result:
other: All animals showed erythema (score 4 of max.4) and edema (score 4 of max.4) from the first observtion time point being reported (24h).
Irritant / corrosive response data:
All animals showed erythema (score 4 of max.4) and edema (score 4 of max.4) from the first observtion time point being reported (24h).
Other effects:
no data

Any other information on results incl. tables

Intact skin, erythema. edema: 24 hr: Score 4 in 6/6; 72 hr: Score 4 in 6/6.
Abraded skin, erythema, edema: 24 hr: Score 4 in 6/6; 72 hr: Score 4 in 6/6.
No tissue destruction and/or necrosis reported, no further details reported.
Summary: irritation score: 8.00/8.00.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Executive summary:

Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading up to 72 hours post application yielded mean irritation score 8 of max 8. reversibility is not reported.