m-cresol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: case report

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: case report

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Brown skin discoloration and black urine along with syncope after dermal exposure of concentrated cresol

Author:

Huang ST

Year:

2012

Bibliographic source:

Journal Emergency Medicine 43, 932-933, 2012

Reference 2

Reference Type:

publication

Title:

black urine after medicinal foot baths

Author:

Liu RL, Huang MY, Huang ST

Year:

2013

Bibliographic source:

BMJ Case Rep 2013. doi:10.1136/bcr-2013-200771

Materials and methods

Study type:

poisoning incident

Endpoint addressed:

dermal absorption

Principles of method if other than guideline:

The case of a 61-year-old male patient who presented to the Emergency Department after dermal exposure with cresol is reported. He had the habit of soaking his feet in cresol-soap solution for 2–3 h three times a week in the last half of the year. This time, he soaked both his feet in a basin filled with 500 mL of 50% cresol-soap solution for 3 h. He was brought to ED by his family.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

all isomers (o-cresol, m-cresol, p-cresol

IUPAC Name:

all isomers (o-cresol, m-cresol, p-cresol

Details on test material:

no data

Method

Subjects:

61-year-old male

Route of exposure:

dermal

Reason of exposure:

intentional

Exposure assessment:

measured

Results and discussion

Clinical signs:

1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure.

Any other information on results incl. tables

The main objective of this report is to provide the characteristic image of cresol poisoning, which may be useful in diagnosis.

Applicant's summary and conclusion

Executive summary:

The case of a 61-year-old male patient who presented to the Emergency Department after dermal exposure with cresol is reported. He had the habit of soaking his feet in cresol-soap solution for 2–3 h three times a week in the last half of the year. This time, he soaked both his feet in a basin filled with 500 mL of 50% cresol-soap solution for 3 h. He was brought to ED by his family.

Results: 1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure. 1) Brownish burns of his feet and black urine after dermal exposure with cresol. 2) Conscious change and syncope. Urine levels of p-cresol, m-cresol, and phenol were 2608, 5391, and 156 mg/g creatinine, respectively, and o-cresol was undetectable at 1 h post-exposure.