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EC number: 203-577-9 | CAS number: 108-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: deficiencies in experimental procedure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Principles of method if other than guideline:
- In accordance with OECD Guideline 475, 5 mice/sex/dose, bone marrow cells, sacrifice 6,24,48 hrs post treatment, negative and positive controls, stat. method: Kruskal-Wallis test.
- GLP compliance:
- yes
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- m-cresol
- Details on test material:
- Test substance: m-cresol, purity: 99.8 %
Constituent 1
Test animals
- Species:
- other: mouse bone marrow cells
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- adult mice (age: 9 weeks at the time of dosing), 5 days for acclimatisation, 5 mice/cage.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- single application, application volume: 5 ml/application.
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Post exposure period:
- no
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 96, 320, 960 mg/kg bw in corn oil
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 mice/sex/dose/ for the 6 hr-, for the 24 hr- and for the 48 hr- period, respectively, post dosing.
- Control animals:
- other: vehicle controls and positive controls (CP)
- Positive control(s):
- yes : CP
Examinations
- Tissues and cell types examined:
- bone marrow cells
- Details of tissue and slide preparation:
- according to guideline
- Evaluation criteria:
- The criteria for a positive response are a statistically significant dose-related increase in the number of structural aberrations at 3 dose levels.
- Statistics:
- Kruskal-Wallis test
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- mortality 3/40 in the highest dose group
clinical signs not attributable to systemic availability
mitotic index in bone marrow cells of treated animals similar to those of controls
Any other information on results incl. tables
The treatment did not increase the frequency of chromosomal aberrations,
indicating that m-cresol was not clastogenic under the conditions of
this assay. The positive control was functional.
Mortality: 3/5 male mice in the 960 mg-group
Signs of toxicity:
960 mg-group: within 10 min after dosing: squinty eyes, scruffy coats,
mild tonic convulsions and rapid breathing which ceased after 30 min.,
breathing difficulties.
320 mg/kg bw: slightly scruffy coats within 22 hours after dosing.
96 mg/kg bw: no signs of toxicity.
Applicant's summary and conclusion
- Executive summary:
m-cresol did not increase chromosomal aberrations in bone marrow cells, however mitotic index in bone marrow cells of treated animals is similar to those of controls.
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