Registration Dossier
Registration Dossier
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EC number: 700-536-1 | CAS number: 25628-08-4
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature (review)
Data source
Materials and methods
Test material
- Reference substance name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- EC Number:
- 249-616-3
- EC Name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- Cas Number:
- 29420-49-3
- IUPAC Name:
- potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
A NOAEL of 300 mg/kg bw/day for maternal toxicity was identified in this study, based on reduced body-weight gains and feed consumption at 1000 mg/kg bw/day.
A NOAEL of 1000 mg/kg bw/day for developmental toxicity was indicated in this study as the reduction in foetal body weights in the 1000 mg/kg bw/day treatment group was less than 10% of the control value and most likely associated with maternal toxicity.
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