Registration Dossier
Registration Dossier
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EC number: 700-536-1 | CAS number: 25628-08-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
no data
Additional information
There are no data available for Tetraethylammonium perfluorobutanesulfonate.
A 2-generation study with potassium perfluorobutane sulfonate was evaluated and cited in the Existing Chemical Hazard Assessment Report by the Australian Government, Department of Health and Ageing, NICNAS, November 2005.
In a two generation reproductive toxicity study in rats administered 0, 30, 100, 300 and 1000 mg PFBS/kg bw/day of the test material, there was no evidence of adverse effects on reproduction, fertility and lactation at the highest dose of 1000 mg/kg bw/day. The NOAEL for reproductive toxicity in males and female P generation is 1000 mg/kg bw/day. The P generation male and female rats NOAEL toxicity was 100 mg/kg bw/day based on treatment-related microscopic changes in the kidney and liver for P-generation males and kidneys for P-generation females, respectively. F1 litter developmental NOAEL was 1000 mg/kg bw/day, the highest dose in the study.The F1 generation male and female rats NOAEL was 100 mg/kg bw/day based on treatment-related microscopic changes in the kidney and liver for males and kidneys for females, respectively, at 300 mg/kg bw/day.
The reproductive NOAEL in the male and female F1 generation rats was 1000 mg/kg bw/day. This dosage had no effect on mating, fertility or maternal delivery parameters. No adverse effects were observed in F2-generation pups in doses as high as 1000 mg/kg bw/day.
Short description of key information:
There are no data available for Tetraethylammonium perfluorobutanesulfonate
Effects on developmental toxicity
Description of key information
There are no data available for Tetraethylammonium perfluorobutanesulfonate
Additional information
There are no data available for Tetraethylammonium perfluorobutanesulfonate.
A prenatal developmental toxicity study with potassium perfluorobutane sulfonate was evaluated and cited in the Existing Chemical Hazard Assessment Report by the Australian Government, Department of Health and Ageing, NICNAS, November 2005.
Female rats administered 0, 100, 300 and 1000 mg PFBS/kg bw/day of the test material on gestation days 6 to 20. A NOAEL of 300 mg PFBS/kg bw/day for maternal toxicity was identified in this study, based on reduced body-weight gains and feed consumption at 1000 mg/kg bw/day. A NOAEL of 1000 mg PFBS/kg bw/day for developmental toxicity was indicated in this study as the reduction in foetal body weights in the 1000 mg/kg bw/day treatment group was less than 10% of the control value and most likely associated with maternal toxicity.
Toxicity to reproduction: other studies
Additional information
no data
Justification for classification or non-classification
Based on the PFBS data cited in the Existing Chemical Hazard Assessment Report by the Australian Government, Department of Health and Ageing, NICNAS, November 2005, a classification is not justified
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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