Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Contribution à l'étude toxicologique de l'alcool n-heptylique primaire
Author:
R.Truhaut
Year:
1974
Bibliographic source:
Archives des maladies Professionnelles de Médecine du Travail. 35, No 4-5, Avril-Mai
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Heptan-1-ol
EC Number:
203-897-9
EC Name:
Heptan-1-ol
Cas Number:
111-70-6
Molecular formula:
C7H16O
IUPAC Name:
heptan-1-ol
Details on test material:
Purity>97%

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml of non diluted sample
Duration of treatment / exposure:
4 hours
Observation period:
24 and 72 hours
Number of animals:
6 rabbits
Details on study design:
0.5 ml of heptanol was applied on 6 rabbits with intact skin and 6 rabbits with or abraded skin.
SCORING SYSTEM: according to the DRAIZE scoring.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24h+72h
Score:
0
Max. score:
4
Reversibility:
no data
Remarks on result:
other: intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24h+72 h
Score:
0
Max. score:
4
Reversibility:
no data
Remarks on result:
other: intact skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24h+72h
Score:
0.75
Max. score:
4
Reversibility:
no data
Remarks on result:
other: abraded skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24h+72h
Score:
0.25
Max. score:
4
Reversibility:
no data
Remarks on result:
other: abraded skin

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information not classified. Criteria used for interpretation of results: EU
Conclusions:
n-heptanol is considered as a slightly irritant.
Executive summary:

The acute dermal irritation of n-heptanol-1 was evaluated in rabbits according to OECD 404 guideline. n-heptanol-1 was applied undiluted to the skin of 6 New-Zealand White albino rabbits and held in contact for 4 hours by means of a semi-occlusive dressing. Mean scores over 24, and 72 hours were 0.75 and 0.25 for erythema and for edema, respectively. Under these experimental conditions, n-heptanol 1 was considered a slightly irritant when applied topically to rabbits.