α,α,α,2-tetrachlorotoluene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α,2-tetrachlorotoluene

EC Number:

218-377-7

EC Name:

α,α,α,2-tetrachlorotoluene

Cas Number:

2136-89-2

Molecular formula:

C7H4Cl4

IUPAC Name:

1-chloro-2-(trichloromethyl)benzene

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: males: 206 g - 320 g

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

1000, 2000 mg/kg bw

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Applicant's summary and conclusion

Conclusions:

The LD50 value for acute dermal toxicity is > 2000 mg/kg bw in male/female Sprague-Dawley rats.