Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α,α,2-tetrachlorotoluene
EC Number:
218-377-7
EC Name:
α,α,α,2-tetrachlorotoluene
Cas Number:
2136-89-2
Molecular formula:
C7H4Cl4
IUPAC Name:
1-chloro-2-(trichloromethyl)benzene

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: males: 206 g - 320 g

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
1000, 2000 mg/kg bw

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Applicant's summary and conclusion

Conclusions:
The LD50 value for acute dermal toxicity is > 2000 mg/kg bw in male/female Sprague-Dawley rats.