α,α,α,2-tetrachlorotoluene

Carcinogenicity

Administrative data

Endpoint:

carcinogenicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α,2-tetrachlorotoluene

EC Number:

218-377-7

EC Name:

α,α,α,2-tetrachlorotoluene

Cas Number:

2136-89-2

Molecular formula:

C7H4Cl4

IUPAC Name:

1-chloro-2-(trichloromethyl)benzene

Test animals

Species:

mouse

Strain:

other: ICR-SLC

Sex:

female

Administration / exposure

Route of administration:

dermal

Vehicle:

other: benzene

Details on exposure:

Control group: 25 µl benzene/animal
Test group: 5µl o-chlorobenzotrichloride / animal

Duration of treatment / exposure:

30 weeks

Frequency of treatment:

Twice per week

Post exposure period:

18 months

No. of animals per sex per dose:

20

Positive control:

no data

Applicant's summary and conclusion

Conclusions:

Despite of methodical weaknesses of this study a carcinogenic potential can not be excluded for the test item.
Thus o-chlorobenzotrichloride should be classified as R40, Limited evidence of a carcinogenic effect, or H351: Suspected of causing cancer, respectivly.

Executive summary:

According to the authors the tumor incidence for o-chlorobenzotrichloride was considerably lower than that for p-chlorobenzotrichloride but significantly increased in relation to the control group.