Ethyl 6,8-dichlorooctanoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22. Sept 1998 to 13. Oct 1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl 6,8-dichlorooctanoate

EC Number:

435-080-1

EC Name:

Ethyl 6,8-dichlorooctanoate

Cas Number:

1070-64-0

Molecular formula:

C10H18Cl2O2

IUPAC Name:

ethyl 6,8-dichlorooctanoate

Test material form:

liquid

Specific details on test material used for the study:

Batch: Ds02-01

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

2000mg/kg

No. of animals per sex per dose:

7 animals per sex and dose

Control animals:

no

Results and discussion

Preliminary study:

one animal per sex were given 200mg/kg and 1000mg/kg and 2000mg/kg. No deaths observed.

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

one of 10 animals

Gross pathology:

all animals were normal at teh post mortem examination

Other findings:

Sedation and distrubed locomotion; Increased salivation and lacrimation and piloerection.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.

Executive summary:

All males and 4/5 females survived until the scheduled termination of the study. One female died on the day of application. No cause of death could be identified.

Body weight and body weight gain of the surviving animals were inconspicuous

All animals were affected by piloerection, increased lacrimation and salivation. this is interpreted as autonomous nervous system effects

Disturbed locomotion , sedation, unconsciousness an righting reflex catalepsy indicate central nervous effects

The signs were observed on the day of the administration of the test substance and lasted until a maximum of 1 d p.a. No toxic effects were noted at later times. The same effects were observed in both esxes.

The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.