Ethyl 6,8-dichlorooctanoate

Endpoint summary

Description of key information

The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.

The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22. Sept 1998 to 13. Oct 1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Specific details on test material used for the study:

Batch: Ds02-01

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

2000mg/kg

No. of animals per sex per dose:

7 animals per sex and dose

Control animals:

no

Preliminary study:

one animal per sex were given 200mg/kg and 1000mg/kg and 2000mg/kg. No deaths observed.

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

one of 10 animals

Gross pathology:

all animals were normal at teh post mortem examination

Other findings:

Sedation and distrubed locomotion; Increased salivation and lacrimation and piloerection.

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.

Executive summary:

All males and 4/5 females survived until the scheduled termination of the study. One female died on the day of application. No cause of death could be identified.

Body weight and body weight gain of the surviving animals were inconspicuous

All animals were affected by piloerection, increased lacrimation and salivation. this is interpreted as autonomous nervous system effects

Disturbed locomotion , sedation, unconsciousness an righting reflex catalepsy indicate central nervous effects

The signs were observed on the day of the administration of the test substance and lasted until a maximum of 1 d p.a. No toxic effects were noted at later times. The same effects were observed in both esxes.

The LD50 of 6,8-dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Quality of whole database:

one study prepared accoding to guideline is available

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Quality of whole database:

Not study necessary for tonnage band 1-10t

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

8. Feb 2000 to 29. Feb 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Limit test:

yes

Specific details on test material used for the study:

Batch: Ds 1099

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

No. of animals per sex per dose:

5

Control animals:

not specified

Preliminary study:

Range finding with 3 animals of each sex:
Dose: 400/894/2000 mg/kg --> all animals survived

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

95% CL:

2 000

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

none

Clinical signs:

other: not substance related

Interpretation of results:

GHS criteria not met

Conclusions:

No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.
No mortality occurred.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.

Executive summary:

No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.

No mortality occurred.

The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Quality of whole database:

one study prepared accoding to guideline is available

Justification for classification or non-classification

Studys according to guideline have been prepared for oral and dermal administration. No deaths occured at the highes dose. Therefore no classification is necessary.