Registration Dossier
Registration Dossier
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EC number: 203-601-8 | CAS number: 108-63-4
Endpoint summary
Administrative data
Description of key information
Additional information
Data on the aquatic toxicity of the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) are not available. Therefore, the aquatic toxicity of the target substance was assessed by means of a read-across approach, through which additional data from a structurally and chemically closely related source substance was compiled in order to fulfil the standard information requirements laid down in Annex XI of REACh Regulation (EC) No 1907/2006. Read-across was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5.
The target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) is a mono-constituent substance. In the present dossier, the target substance will be assessed on the basis of aquatic toxicity data compiled from the source substances Bis(7-methyloctyl) adipate (CAS 33703-08-1), Dioctyl adipate (CAS 123-79-5) and Bis(2-ethylhexyl) adipate (CAS 103-23-1). The source substances were selected on the basis of structural similarities and similarities in properties and/or activities to the target substance, with due regard of the requirements for adequacy and reliability of data. Based on the high degree of similarity between the structural and physico-chemical properties of the target and the source substances, it is assumed that the target substance will have a similar ecotoxicological profile as the selected source substances. A detailed read-across justification is provided in IUCLID section 13. The available short-term and long-term toxicity studies on the source substances determined no acute or chronic effects of the source substances within the limits of water solubility. Detrimental effects on aquatic microorganisms were not observed in the available read-across studies.
Therefore, it can be concluded that the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) presumably does not cause short-term or long-term toxicity to aquatic organisms within the limits of water solubility (0.0042 mg/L at 20 °C, pH ca. 5.9) and is not expected to affect the degradation process in commercial sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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