Registration Dossier
Registration Dossier
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EC number: 203-601-8 | CAS number: 108-63-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily Biodegradable: > 67% in 28 d (WoE, read-across)
Key value for chemical safety assessment
Additional information
Studies testing the ready biodegradability of Bis(1-methylheptyl) adipate (CAS 108-63-4)are not available. The assessment is based on read-across data available for thestructurally and chemically closely related source substances Bis(2-ethylhexyl) adipate (CAS 103-23-1), Dioctyl adipate(CAS 123-79-5) and Bis(6-methylheptyl) adipate (CAS 1330-86-5). The read-across was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, section 1.5 in order to fulfil the data requirements for this substance. This read-across is justified in detail within the analogue justification in IUCLID Section 13.
The source substanceBis(2-ethylhexyl) adipate (CAS 103-23-1) reached a biodegradation rate of 96% after 28 days in a guideline study following OECD 301B. The biodegradability of the source Dioctyl adipate (CAS 123-79-5) was tested in a study according to OECD guideline 301D at test substance concentrations of 2 and 5 mg/L, respectively. Degradation rates were >67% after 30 d for both test concentrations. The source Bis(6-methylheptyl) adipate (CAS 1330-86-5) was degraded by 70.22% after 28 d in a study according to OECD 301F. All tests on the source substances were performed with non-adapted activated sludge as inoculum and the ten-day window criterion was met in all three studies.
Based on the available results from structurally related read-across substances (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4) is readily biodegradable.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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