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EC number: 459-520-5 | CAS number: 132182-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity tests showed that the LD50 of the testsubstance is higher than 2000 mg/kg body weight, both after oral and after dermal administration. The NOAEL after oral administration for 28 days revealed a NOAEL of 150 mg/kg/day. Inhalation toxicity tests have been performed and the acute inhalation test resulted in an LC50 higher than 30000 ppm (60% of the saturated vapor pressure) and the NOAEL after 5 days inhalation was higher than 10000 ppm. Therefore, an extensive toxicokinetic assessment is considered of limited value. Below, a summary of the anticipated toxicokinetic behavior of the test substance is given.
Key value for chemical safety assessment
Additional information
ABSORPTION
The water solubility of the test substance is extremely low (295 ug/l), caused by presence of apolar side groups in the molecule. In general, a compound needs to be dissolved before it can be taken up from the gastro-intestinal tract after oral administration (1). Thus, the extremely low water solubility can be considered a potentially rate-limiting factor for the absorption of the compound. However, in the presence of food and bile salts the systemic exposure might be a little higher. Overall, it is to be expected that the oral bioavailability, and thus the systemic exposure, of the test substance will be relatively low. Uptake via inhalation is anticipated to be low. Because of the low water solubility and the high vapour pressure (6.25 kPa) of the test substance, absorption across the lung/blood interface is expected to be negligible
Since it is generally accepted that substances with log Pow ranging from 0.1 to 6 penetrate the skin easily (2), it is to be expected that the test substance will penetrate the skin to some extent. However, unless the test substance is prevented from evaporating from the surface of the skin, it is expected the high volatility would preclude meaningful skin absorption. In conclusion, it is expected that absorption through normal industrial routes of exposure will be very low.
DISTRIBUTION
The test substance will show a high volume of distribution. Therefore, the very low amount of absorbed material will be reversibly distributed into peripheral tissue, especially fatty tissues. The plasma protein binding is expected to be high.
METABOLISM AND EXCRETION
Pulmonary excretion will occur via the lungs. It is anticipated that the larger part of the test substance will be excreted this way.
In the liver, metabolic oxidation will occur. Other segregated hydrofluoroethers are known to undergo oxidation and to be dehalogenated by cytochrome P450. (HFE-7100, HFE-7200: ELINCS 422-270-2 : 425-340-0, respectively).
Metabolites may be excreted via exhalation or via urine or bile. Limited cleavage of the ether bond is anticipated.
CONCLUSION
Based on the expected kinetic behavior in the body, as described above, the test substance will show low absorption through all routes of exposure. After absorption, excretion will mainly be via the lungs. Additionally, the test substance will be metabolized in the liver. Metabolites can be excreted via lungs, or bile or urine. Therefore, it is unlikely accumulation will occur in the body during prolonged exposure.
REFERENCES
1. Martinez MN, Amidon GL. Mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol 2002; 42: 620-43.
2. T.G. Vermeire et al., Estimation of consumer exposure to chemicals: application of simple models. The Science of the Total Environment 1993; 136: 155-76.
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