Registration Dossier
Registration Dossier
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EC number: 459-520-5 | CAS number: 132182-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Surface tension
Administrative data
- Endpoint:
- surface tension
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because water solubility is below 1 mg/L at 20°C
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 10, 2012 - September 14, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP without restriction.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 295 µg/L
- Temp.:
- 30 °C
- Remarks on result:
- other: pH was not measured
- Details on results:
- Water solubility reported as ng/mL.
Triplicate samples were incubated for three time points (1, 2, and 3 days) at approximately 30 °C. Triplicate analysis was performed for each sample at each time point. The average measured solubilities for day 1 was 291 (250 -307) ng/mL; the average measured solubilities for day 2 was 293 (227 - 320) ng/mL; and the average measured solubilities for day 3 was 303 (280 - 320) ng/mL. An overall average value of 295 ng/mL was reported. The average %RSD for days 1, 2 and 3 were 5.7%, 17%, and 3.4%, respectively, Overall %RSD was 10%, meeting the sample precision requirements of ≤ 20% (%RSD). - Conclusions:
- Under conditions of this study, the water solubility of Novec 7300 is 295 ng/mL.
- Executive summary:
The solubility of HFE-7300 in Milli-Q water was determined using the Shake Flask method according to OPPTS 830.7840. Triplicate samples were incubated for 1, 2, and 3 days at approximately 30 °C. Samples were equilibrated at room temperature for 24 hours prior to analysis. Concentrations were analyzed in triplicate using a purge and trap gas chromatography/mass spectrometry (GC/MS).
HFE-7300 has a measured water solubility of 295 ng/mL at approximately 30˚C, as an average of day 1,2, and 3 measurements. The overall %RSD was 10%.
This is a guideline study conducted under GLP compliance. The study meets test requirements with no deviation. Therefore, it is considered reliable without restrictions.
Table 1. Summary of HFE-7300 Water Solubility in MiIIi-Q Water.
|
Day 1 |
Day 2 |
Day 3 |
|||
Sample |
Avg. Conc. (ng/mL) |
% RSD |
Avg. Conc. (ng/mL) |
% RSD |
Avg. Conc. (ng/mL) |
% RSD |
Vial 1 |
278 |
8.5 |
229 |
0.81 |
295 |
4.4 |
Vial 2 |
304 |
1.0 |
339 |
0.20 |
303 |
0.47 |
Vial 3 |
291 |
1.5 |
311 |
2.5 |
309 |
3.2 |
Intra-day Average |
291 |
5.7 |
293 |
17 |
303 |
3.4 |
Overall average |
295 ng/mL |
|||||
Overall %RSD |
10 |
Table 2. Water solubility results of HFE-7300
Day 1 solubility Data (ng/mL) |
|||||
Samples |
Rep 1 |
Rep 2 |
Rep 3 |
Average Conc. (ng/mL) |
% RSD |
Vial 1 |
250 |
294 |
288 |
278 |
8.5 |
Vial 2 |
307 |
302 |
301 |
304 |
1.0 |
Vial 3 |
286 |
293 |
293 |
291 |
1.5 |
Average |
|
|
|
291 |
|
RSD% |
|
|
|
5.7% |
|
Day 2 solubility Data |
|||||
Samples |
Rep 1 |
Rep 2 |
Rep 3 |
Average Conc. (ng/mL) |
% RSD |
Vial 1 |
229 |
227 |
231 |
229 |
0.81 |
Vial 2 |
339 |
339 |
338 |
339 |
0.2 |
Vial 3 |
306 |
320 |
307 |
311 |
2.5 |
Average |
|
|
|
293 |
|
RSD% |
|
|
|
17 |
|
Day 3 solubility Data |
|||||
Samples |
Rep 1 |
Rep 2 |
Rep 3 |
Average Conc. (ng/mL) |
% RSD |
Vial 1 |
304 |
280 |
302 |
295 |
4.4 |
Vial 2 |
303 |
302 |
305 |
303 |
0.47 |
Vial 3 |
301 |
306 |
320 |
309 |
3.2 |
Average |
|
|
|
303 |
|
RSD% |
|
|
|
3.4 |
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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