1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)pentane

Surface tension

Administrative data

Endpoint:

surface tension

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because water solubility is below 1 mg/L at 20°C

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 10, 2012 - September 14, 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study under GLP without restriction.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Water solubility:

295 µg/L

Temp.:

30 °C

Remarks on result:

other: pH was not measured

Details on results:

Water solubility reported as ng/mL.

Triplicate samples were incubated for three time points (1, 2, and 3 days) at approximately 30 °C. Triplicate analysis was performed for each sample at each time point. The average measured solubilities for day 1 was 291 (250 -307) ng/mL; the average measured solubilities for day 2 was 293 (227 - 320) ng/mL; and the average measured solubilities for day 3 was 303 (280 - 320) ng/mL. An overall average value of 295 ng/mL was reported. The average %RSD for days 1, 2 and 3 were 5.7%, 17%, and 3.4%, respectively, Overall %RSD was 10%, meeting the sample precision requirements of ≤ 20% (%RSD).

Table 1. Summary of HFE-7300 Water Solubility in MiIIi-Q Water.

 

	Day 1		Day 2		Day 3
Sample	Avg. Conc. (ng/mL)	% RSD	Avg. Conc.  (ng/mL)	% RSD	Avg. Conc.  (ng/mL)	% RSD
Vial 1	278	8.5	229	0.81	295	4.4
Vial 2	304	1.0	339	0.20	303	0.47
Vial 3	291	1.5	311	2.5	309	3.2
Intra-day Average	291	5.7	293	17	303	3.4
Overall average	295 ng/mL
Overall %RSD	10

Table 2. Water solubility results of HFE-7300

Day 1 solubility Data (ng/mL)
Samples	Rep 1	Rep 2	Rep 3	Average Conc. (ng/mL)	% RSD
Vial 1	250	294	288	278	8.5
Vial 2	307	302	301	304	1.0
Vial 3	286	293	293	291	1.5
Average				291
RSD%				5.7%
Day 2 solubility Data
Samples	Rep 1	Rep 2	Rep 3	Average Conc. (ng/mL)	% RSD
Vial 1	229	227	231	229	0.81
Vial 2	339	339	338	339	0.2
Vial 3	306	320	307	311	2.5
Average				293
RSD%				17
Day 3 solubility Data
Samples	Rep 1	Rep 2	Rep 3	Average Conc. (ng/mL)	% RSD
Vial 1	304	280	302	295	4.4
Vial 2	303	302	305	303	0.47
Vial 3	301	306	320	309	3.2
Average				303
RSD%				3.4

Conclusions:

Under conditions of this study, the water solubility of Novec 7300 is 295 ng/mL.

Executive summary:

The solubility of HFE-7300 in Milli-Q water was determined using the Shake Flask method according to OPPTS 830.7840. Triplicate samples were incubated for 1, 2, and 3 days at approximately 30 °C. Samples were equilibrated at room temperature for 24 hours prior to analysis. Concentrations were analyzed in triplicate using a purge and trap gas chromatography/mass spectrometry (GC/MS).

HFE-7300 has a measured water solubility of 295 ng/mL at approximately 30˚C, as an average of day 1,2, and 3 measurements. The overall %RSD was 10%.

This is a guideline study conducted under GLP compliance. The study meets test requirements with no deviation. Therefore, it is considered reliable without restrictions.