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EC number: 459-520-5 | CAS number: 132182-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 02 May 2005 to 27 May 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted in compliance with GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: The study was conducted according to a custom protocol.
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Four rats were whole body exposed to the test material at 10000 ppm (143.2 mg/L, vapor) for 6 hours a day for 10 days. Animals were observed during exposure and through the remainder of a 14 day observation period.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- s-601
- IUPAC Name:
- s-601
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): s-601
- Substance type: Clear, colorless liquid
- Physical state: Liquid
- Analytical purity: 99.959%
- Purity test date: 10 June 2005
- Lot/batch no.: 41-2601-2240-7
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 202-222 grams
- Fasting period before study: None
- Housing: Individually in metabolism cages
- Diet (e.g. ad libitum): Harlan Teklad LM-485 Mouse/Rat Sterilizable Diet ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6-23.9
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From: 02 May 2005 To: 27 May 2005
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 40 liter plexiglass chamber specially designed to observe animal exposure to volatile fluorochemicals. 3.45 ml of the test article was added to the 40 L chamber to generate the exposure atmosphere.
- Method of holding animals in test chamber: No data
- Source and rate of air: no data
- Method of conditioning air: No data
- Temperature, humidity, pressure in air chamber: No data
- Air flow rate: No data
- Air change rate: no data
- Treatment of exhaust air: No data
TEST ATMOSPHERE
- Brief description of analytical method used: No data
- Samples taken from breathing zone: no data - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Animals were exposed to the test atmosphere for 6 hours a day for 10 days.
- Frequency of treatment:
- Daily for 10 days.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 (control) or 10000 ppm (143.2 mg/L, vapor)
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 males were exposed to the test article.
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Dose selection rationale: Based on previous studies
- Rationale for animal assignment (if not random): Random - Positive control:
- Not applicable
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: Continuously during exposure, daily thereafter
DETAILED CLINICAL OBSERVATIONS: Yes / No / No data
- Time schedule:
BODY WEIGHT: Yes
- Time schedule for examinations: Prior to first exposure and daily thereafter
URINALYSIS: Yes
- Time schedule for collection of urine: Study days 4, 7, 12, and 14.
- Metabolism cages used for collection of urine: Yes
- Animals fasted: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: No data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- effects observed, treatment-related
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- CLINICAL SIGNS AND MORTALITY: No abnormal clinical signs or mortality were observed during the study.
BODY WEIGHT AND WEIGHT GAIN: All animals gained weight during the study.
URINALYSIS: The concentration of both acid and fluoride metabolites among all test animals was comparable.
GROSS PATHOLOGY: No toxicologically relevant results were noted.
Effect levels
- Dose descriptor:
- other: 10-day LC50
- Effect level:
- > 143.2 mg/L air (nominal)
- Sex:
- male
- Basis for effect level:
- other: clinical signs; mortality; body weight; urinalysis; gross pathology; organ weights
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the results of the study, the 10-day inhalation LC50 is greater than 10000 ppm (143.2 mg/L, vapor).
- Executive summary:
The 10-day inhalation toxicity potential of the test article was determined in male Sprague-Dawley rats. Rats (4/group) were exposed, whole body, to the test material at 0 (control), or 10000 ppm (143.2 mg/L, vapor) for 6 hours a day for 10 days. Clinical observations (continuously during exposure and daily thereafter), body weights (prior to initial exposure, and daily thereafter) were recorded. Urine samples were collected on days 4, 7, 12, and 14 post exposure for urinalysis. Gross necropsy was conducted 14 days after the last exposure. No mortality or abnormal clinical signs were noted during the study period. Concentrations of both acid and fluoride metabolites among all test animals were comparable. All animals gained weight during the study period. No abnormalities were found upon gross necropsy. Based on the results of the study, the 10-day inhalation LC50 is greater than 10000 ppm (143.2 mg/L, vapor).
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