Registration Dossier
Registration Dossier
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EC number: 202-461-5 | CAS number: 95-87-4
Endpoint summary
Administrative data
Description of key information
Skin and Eye irritation/corrosion:
According to the harmonised classification and labeling approved by the EU, the substance causes severe skin burns and eye damage.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion:
No information is available on 2,5-xylenol regarding skin irritation/corrosion. 2,5 -xylenol is classified as corrosive to skin and eye under Annex VI of the CLP regulation.
Information on skin irritation properties of 3,5 -xylenol ist contradictory. An in vivo study performed with 3,5 -xylenol shows no skin irritation potential, whereas studies on other xylenol and cresol isomers clearly show a highly irritating property (ECHA disseminated dossier, CAS: 1300 -71 -6).
Eye irritation:
No information is available on 2,5-xylenol regarding eye irritation. 2,5-xylenol is classified as corrosive to skin and eye under Annex VI of the CLP regulation.
3,5-Xylenol was found to be highly irritating to the rabbit's eye when tested in New Zealand white rabbits (ECHA disseminated dossier, CAS: 1300 -71 -6).
Justification for classification or non-classification
2,5 -xylenol is classified as corrosive to skin and eye under Annex VI of the CLP regulation and therefore H314 (causes severe skin burns and eye damage) applies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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