Registration Dossier
Registration Dossier
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EC number: 202-461-5 | CAS number: 95-87-4
Endpoint summary
Administrative data
Description of key information
Only limited information is available regarding acute toxicity of the
test item.
Oral LD50 values for mouse, rat and rabbit indicate an oral toxicity of
the test item in the range of 383-938 mg/kg bw (LD50).
This result is supported by a guideline study on mixed xylenols with an oral LD50 of 980 mg/kg bw (ECHA disseminated dossier CAS: 1300 -71 -6).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from collection of data, no details on methods and results
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 444 mg/kg bw
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 444 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the NTP data base and the repository for the test item several LD50 values are specified without detailed information:
LD 50 oral mouse: 383 mg/kg bw
LD 50 oral rat: 444 mg/kg bw
LD 50 oral rabbit: 938 mg/kg bw
Justification for selection of acute toxicity – oral endpoint
Only supporting study data available.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008:
Based on the available data the substance is considered to be classified for acute oral toxicity as Acute Tox Cat 4 , H302 under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation EC 605/2014.
As the test item is officially classified as Acute Tox 3, H301 and H311 under Regulation (EC) No 1272/2008 (Annex VI), as amended for the sixth time in Regulation EC 605/2014, this classification is followed.
Aspiration is a known hazard of hydrocarbons and classification is based on the physical characteristics and therefore classification with Cat.1, H304 "May be fatal if swallowed and enters airways" is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
