Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Expert assessment
Adequacy of study:
key study
Study period:
August 11, 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.

Data source

Reference
Reference Type:
other: Expert assessment
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.
GLP compliance:
no
Test type:
other: Assessment based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route.
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[(2-hydroxyethyl)thio]propan-2-ol
EC Number:
229-765-0
EC Name:
1-[(2-hydroxyethyl)thio]propan-2-ol
Cas Number:
6713-03-7
Molecular formula:
C5H12O2S
IUPAC Name:
1-[(2-hydroxyethyl)sulfanyl]propan-2-ol

Test animals

Sex:
male/female

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
other: weight of evidence

Any other information on results incl. tables

see attached report.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
1-[(2-hydroxyethyl)thio]propan-2-ol is expected to have a low acute oral toxicity with an LD50 > 2000 mg/kg.
Executive summary:

An assessment was performed based on the outcome of a short-term repeated-dose toxicity study performed on the substance via the oral route to determine the acute oral toxicity of the registered substance. As a conclusion 1-[(2-hydroxyethyl)thio]propan-2-ol is expected to have a low acute oral toxicity with an LD50 > 2000 mg/kg. The substance did not meet the criteria for classification according to Regulation (EC) No.1272/2008.