Registration Dossier
Registration Dossier
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EC number: 229-765-0 | CAS number: 6713-03-7
Endpoint summary
Administrative data
Description of key information
The toxicity to the aquatic environment of 1-[(2-hydroxyethyl)thio]propan-2-ol was investigated by performing GLP-compliant short-term toxicity studies to freshwater aquatic invertebrates and algae, and by performing an expert assessment on the short-term toxicity to freshwater fish based on valid QSAR predictions and literature data on an analogue substance.
Fish was identified as the most sensitive species based on the outcome of the investigation with a 96h LC50of 144 mg/L. Considering that the lowest L(E)C50for 1-[(2-hydroxyethyl)thio]propan-2-ol is above 1 mg/L, the substance does not meet the criteria for classification as Aquatic Acute 1; H400 in accordance with Regulation (EC) N° 1272/2008.
There is no available data on the chronic toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to the aquatic environment. As the substance is being registered under REACH in the 10-100 tonnage band there is no requirement for information on long-term studies to aquatic species. Therefore the classification of the registered substance for chronic effects is based on the short-term toxicity of 1-[(2-hydroxyethyl)thio]propan-2-ol to the aquatic environment and its ready biodegradability. Considering that the lowest L(E)C50for 1-[(2-hydroxyethyl)thio]propan-2-ol is above 100 mg/L, the substance does not meet the criteria for classification for long lasting effects to the aquatic environment in accordance with Regulation (EC) N° 1272/2008.
In accordance with Annex VIII of REACH, Column 2, activated sludge respiration inhibition testing does not need to be conducted if there is no emission to a sewage treatment plant. 1-[(2-hydroxyethyl)thio]propan-2-ol is not made available on the EU market as a monomer and is imported already polymerised. Therefore no emission to a sewage treatment plant is expected and testing does not need to be conducted.
A toxicity control was performed during the GLP-compliant ready biodegradability study performed according to the OECD Testing Guideline 301D. As a result of this control it is concluded that 1-[(2-hydroxyethyl)thio]propan-2-ol is not inhibitory to bacteria at the concentrations tested.
Additional information
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