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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May - September 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
Pow
Partition coefficient:
0.05
Temp.:
22.3 °C
pH:
>= 10.9 - <= 11.1
Remarks on result:
other: This is the value measured for the neat product.
Type:
log Pow
Partition coefficient:
-1.31
Temp.:
22.3 °C
pH:
>= 10.9 - <= 11.1
Remarks on result:
other: This is the value measured for the neat product.
Type:
Pow
Partition coefficient:
5.5
Temp.:
22.3 °C
pH:
7
Remarks on result:
other: Calculated value, considering the pKa of AMPD to be 8.95.
Type:
log Pow
Partition coefficient:
-3.3
Temp.:
22.3 °C
pH:
7
Remarks on result:
other: Calculated value, considering the pKa of AMPD to be 8.95.

Description of key information

log Kow = -1.31 at 22 °C; Corrected logKow at pH 7 = -3.3.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.31
at the temperature of:
22 °C

Additional information

Shake flask method, OECD 107 under GLP, supported by an older non-GLP study.