2-amino-2-methylpropane-1,3-diol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May - September 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP Study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

>= 74.7 other: % w/w solution

Temp.:

20 °C

pH:

>= 11.4 - <= 12.3

Remarks on result:

other: The pH of the solutions ranged from 11.4 to 12.3 as the concentration increased from 5.03 to 74.7 % w/w.

The sample concentrations, observations and solution pH are shown in the following tables:

Sample	Concentration (% w/w)	Observations	Solution pH
1	5.03	Clear, non-viscous liquid, no excess, undissolved test item.No Tyndall beam observed.	11.4
2	25.3	Clear, non-viscous liquid, no excess, undissolved test item.No Tyndall beam observed.	11.8
3	49.6	Clear, non-viscous liquid, no excess, undissolved test item.No Tyndall beam observed.	12.1
4	74.7	Clear, very viscous liquid, no excess, undissolved test item.Slight Tyndall beam observed.	12.3
5	95.3	Damp, white crystals/powder, a small amount of excess liquid visible.	*

Sample	Concentration (% w/w)	Observations	Solution pH
6	80.2	Clear, colorless, highly viscous liquid, with much excess test item floating in the solution both at the base and stuck to the sides of the vessel.	*
7	85.1	Very small amount of clear, colorless, highly viscous liquid, with much excess test item floating in the solution at the base and stuck to the sides of the vessel. The liquid appears to have been almost totally absorbed into the test item, forming a layer of excess test item at the base of the vessel, but wet in appearance.	*
8	89.2	Very small amount of clear, colorless, highly viscous liquid, with much excess test item floating in the solution at the base and stuck to the sides of the vessel. The liquid appears to have been almost totally absorbed into the test item, forming a layer of excess test item at the base of the vessel, but wet in appearance.	*

Conclusions:

The water solubility of the test substance is >= 74.7 % w/w at 20 °C.

Description of key information

>= 74.7 % w/w at 20 °C

Key value for chemical safety assessment

Water solubility:

747 g/L

at the temperature of:

20 °C