Registration Dossier
Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- No information
- Author:
- Zub M (1978). Reactivity of the white blood cell system to toxic action benzene and its derivatives. Acta Biol. 21, 163-174
Materials and methods
- Principles of method if other than guideline:
- Method: other: 5 mice/sex, whole-body exposure
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: Trichlorobenzene isomere not specified, no data on purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 3 weeks, 3 months
- Frequency of treatment:
- daily, 7 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 weeks: 500 mg/m³, 3 months: 20 mg/m³
Basis
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
3-weeks exposure:
all animals survived, hypoactivity, lack of appetite, matted hair
Leukopenia, lymphocytosis in the peripheral blood, fatty degeneration in the liver
3 months exposure:
body weight loss, matted hair, drowsiness,
Leukopenia, lymphocytosis, neutropenia, degenerative changes in the thymus,intense desintegration of lymphocytes
Applicant's summary and conclusion
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