Registration Dossier
Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- No information
- Author:
- Ariyoshi T. et al. (1975). Relationship beween chemical structure and activity. II. Influence of isomers in dichlorobenzene, trichlorobenzene and tetrachlorobenzene on the activities of drug-metabolizing enzymes. Chem. Pharm. Bull.23, 824-830
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Method: other: see freetext
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, no data on purity
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: traganth gum solution
- Duration and frequency of treatment / exposure:
- 3 day(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Females: 0 or 250 mg/kg bw in 2% traganth gum solution
- No. of animals per sex per dose / concentration:
- Females: 6
Results and discussion
Any other information on results incl. tables
RS-Freetext:
body weight development and liver weights were affected by treatment.
The only parameters which were significant different from controls were (mean values of 6 rats):
Microsomal protein content:
18.3 mg/g liver versus 16.9 mg/g liver in control rats
Microsomal phosphorus content:
299 µg/g liver versus 238 µg/g liver in control rats
Cytochromes P-450:
0.84 nmoles/mg protein versus 0.70 nmoles/mg protein in control rats
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
