Registration Dossier
Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- No information
- Author:
- Ariyoshi T. et al. (1975). Relationship beween chemical structure and activity. II. Influence of isomers in dichlorobenzene, trichlorobenzene and tetrachlorobenzene on the activities of drug-metabolizing enzymes. Chem. Pharm. Bull.23, 824-830
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Method: other: see freetext
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, no data on purity
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: traganth gum solution
- Duration and frequency of treatment / exposure:
- 3 day(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Females: 0 or 250 mg/kg bw in 2% traganth gum solution
- No. of animals per sex per dose / concentration:
- Females: 6
Results and discussion
Any other information on results incl. tables
RS-Freetext:
body weight development and liver weights were affected by treatment.
The only parameters which were significant different from controls were (mean values of 6 rats):
Microsomal protein content:
18.3 mg/g liver versus 16.9 mg/g liver in control rats
Microsomal phosphorus content:
299 µg/g liver versus 238 µg/g liver in control rats
Cytochromes P-450:
0.84 nmoles/mg protein versus 0.70 nmoles/mg protein in control rats
Applicant's summary and conclusion
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