Registration Dossier
Registration Dossier
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EC number: 500-315-8 | CAS number: 127087-87-0 1 - 2.5 moles ethoxylated
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from NTRL reports
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- FINAL REPORT, PRIMARY DERMAL IRRITATION AND OCULAR IRRITATION (RABBIT), AND ACUTE ORAL TOXICITY (RAT) OF NONYLPHENOL ETHOXYLATES (NPES), WITH COVER LETTER DATED 10/14/96
- Author:
- LONZA INC
- Year:
- 1 996
- Bibliographic source:
- OTS0558916, submitted by LONZA INC.; last updated 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary Dermal irritation test was performed on rabbits to evaluate the irritation potential of 4-Nonylphenol, branched, ethoxylated
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-Nonylphenol, branched, ethoxylated
- EC Number:
- 500-315-8
- EC Name:
- 4-Nonylphenol, branched, ethoxylated
- Cas Number:
- 127087-87-0
- Molecular formula:
- C25H44O6
- IUPAC Name:
- 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type:Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula: C17H28O2
- Molecular weight: 264.409 g/mol
- Substance type: Organic
SMILES: CCCC(C)CC(C)Cc1ccc(OCCOCCOCCOCCOCCO)cc1
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Sex: Male and female
- Source: Summit View Farm, Belvidere, New Jersey, USA
Diet (e.g. ad libitum): ad libitum with Wayne animal feeds used exclusively
- Water (e.g. ad libitum): ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and non abraded
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- no data available
- Observation period:
- 24 and 72 hours observation
- Number of animals:
- 6
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The Primary Dermal Irritation Index of 4-Nonylphenol, branched, ethoxylated was 0.0.
Based on the scores and observations, 4-Nonylphenol, branched, ethoxylated was considered as not irritating to rabbit skin. - Executive summary:
Primary Dermal irritation test was performed on rabbits to evaluate the irritation potential of 4-Nonylphenol, branched, ethoxylated .
6 male & female rabbits were used for the study. 0.5 ml single application of 4-Nonylphenol, branched, ethoxylated ( Carsonon N-10, 5% Active in distilled water) under occluded patch was applied to abraded and non abraded skin of rabbits.The effects were observed at 24 and 72 hours and reactions were scored.
The Primary Dermal Irritation Index of 4-Nonylphenol, branched, ethoxylated was 0.0.
Based on the scores and observations, 4-Nonylphenol, branched, ethoxylated was considered as not irritating to rabbit skin.
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