4-Nonylphenol, branched, ethoxylated

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

05/02/1979 to 27/03/1979

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary source

Data source

Reference

Reference Type:

secondary source

Title:

FINAL REPORT, PRIMARY DERMAL IRRITATION AND OCULAR IRRITATION (RABBIT), AND ACUTE ORAL TOXICITY (RAT) OF NONYLPHENOL ETHOXYLATES (NPES), WITH COVER LETTER DATED 10/14/96

Author:

LONZAINC

Year:

1996

Bibliographic source:

OTS0558916, CONSUMER PROD TESTING CO INC, page no 1-15

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity study of Carsonon N-10 in rats

GLP compliance:

not specified

Test type:

other: No data

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-Nonylphenol, branched, ethoxylated

EC Number:

500-315-8

EC Name:

4-Nonylphenol, branched, ethoxylated

Cas Number:

127087-87-0

Molecular formula:

C25H44O6

IUPAC Name:

2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type:Organic
- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Poly(oxy-1,2-ethanediyl), .alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched
- Molecular formula (if other than submission substance): C23H40O5
- Molecular weight (if other than submission substance): 396.63 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rat

Strain:

other: Albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source:Summit View Farm, Belvidere, New Jersey
- Age at study initiation:No data available
- Weight at study initiation:194-244 g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): with Wayne animal feeds used exclusively, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

DOSAGE PREPARATION (if unusual): 100 %

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5 male, 5 female

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality observed

Mortality:

When treated wtih 5000 mg/kg bw, all the treated male and female rats were dead

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Any other information on results incl. tables

Dose Level (g/kg)	Sex	Dead/ dosed	%
5.0	5M/ 5F	5/5 : 5/5	100

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 was considered to be < 5000 mg/kg bw when male and female rats were treated with Carsonon N-10 (Poly(oxy-1,2-ethanediyl), .alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched ) orally.

Executive summary:

In a acute oral toxicity study, male and female rats by using Carsonon N-10 (Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, branched) in the concentration of 5000 mg/kg bw orally. All the treated male and female rats were dead at 5000 mg/lg bw. Therefore, LD50 was considered to be < 5000 mg/kg bw when male and female rats were treated with Carsonon N-10 (Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-, branched) orally.