Registration Dossier
Registration Dossier
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EC number: 202-311-9 | CAS number: 94-18-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In an in-vitro study conducted with Benzyl 4-hydroxybenzoate (Synonym: benzyl paraben) using human liver microsomes, the hydrolysis of the paraben occurred more rapidly than in plasma. The hydrolysis rate followed first-order kinetics, thus allowing the determination of hydrolysis rate constants and half-lives. The benzyl paraben had a half-life of 43 min. Benzyl paraben is metabolized to benzylparaben-4 O-glucuronide. This active biotransformation is likely to prevent the accumulation of these molecules in man and thus prevent their possible toxicity.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In an in-vitro study conducted with Benzyl 4-hydroxybenzoate (Synonym: benzyl paraben) using human liver microsomes,the hydrolysis of the paraben occurred more rapidly than in plasma. The hydrolysis rate followed first-order kinetics, thus allowing the determination of hydrolysis rate constants and half-lives. The benzyl paraben had a half-life of 43 min. Benzyl paraben is metabolized to benzylparaben-4 O-glucuronide.This active biotransformation is likely to prevent the accumulation of these molecules in man and thus prevent their possible toxicity. The results suggest that these parabens do not accumulate in human tissue.
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